Melatonin and thermal stress regulate differential expression of heat shock proteins and melatonin receptors in spleen of mice.

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dc.contributor.authorAcharjee, Samik
dc.contributor.authorSingh, Shiv Shankar
dc.date.accessioned2016-12-09T04:23:13Z
dc.date.available2016-12-09T04:23:13Z
dc.date.issued2015-01
dc.description.abstractCellular defence by expression of heat shock proteins (Hsps) against stress stimulation is the most universal phenomenon in stress physiology. Melatonin is well known as an anti-stress molecule possessing hypothermic effects. It protects cells and tissues in stressed conditions. Individually, Hsp70 and melatonin shows its functional ability in stressed organisms as well as in immune functions. The aim of the present study was to determine the interaction of melatonin receptors (MT1/MT2) in exogenous melatonin modulated expression of heat shock proteins (Hsp70/Hsc70) in spleen of thermally stressed male mice. Results of the study showed thermal stress significantly increased the Hsp70/Hsc70 and melatonin receptor MT2 expression in spleen of mice. The administration of melatonin significantly increased Hsp70 expression, but decreased Hsc70 expression. Both MT1/MT2 receptor expressions increased after melatonin treatment, whereas thermal stress to melatonin treated mice showed decrease in MT1/MT2 receptor expression than the only melatonin treated mice. MT2 receptor is responding in all experimental conditions corresponding to changes in Hsp70 protein expression. Therefore, the present study might suggest that MT2 receptor is interacting in coordination of melatonin mediated heat shock proteins expression in mice spleen after thermally stressed conditions.en_US
dc.identifier.citationSamik Acharjee, Shiv Shankar Singh. Melatonin and thermal stress regulate differential expression of heat shock proteins and melatonin receptors in spleen of mice. Indian Journal of Pharmaceutical & Biological Research. 2015 Jan-Mar; 3(1): 36-47.en_US
dc.identifier.issn2320-9267
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/179585
dc.language.isoenen_US
dc.source.urihttps://ijpbr.in/pdf/Melatonin-and-thermal-stress-regulate-differential-expression-of-heat-shock-proteins-and-melatonin-receptors-in-spleen-of-mice.pdfen_US
dc.subjectHeat shock proteinsen_US
dc.subjectmelatonin receptorsen_US
dc.subjectmiceen_US
dc.subjectspleenen_US
dc.subjectthermal stressen_US
dc.titleMelatonin and thermal stress regulate differential expression of heat shock proteins and melatonin receptors in spleen of mice.en_US
dc.typeArticleen_US
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