Serum N-terminal pro-brain natriuretic peptide in normal Thai subjects.

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dc.contributor.authorLeowattana, Wattanaen_US
dc.contributor.authorSirithunyanont, Chirasaken_US
dc.contributor.authorSukumalchantra, Yosvien_US
dc.contributor.authorChaisupamonkollarp, Somsaken_US
dc.contributor.authorWatanawaroon, Sermkiten_US
dc.contributor.authorChivatanaporn, Bhanuen_US
dc.contributor.authorKangkagate, Charuwanen_US
dc.contributor.authorMahanonda, Nithien_US
dc.contributor.authorBhuripanyo, Kiertijaien_US
dc.date.accessioned2009-05-27T20:39:26Z
dc.date.available2009-05-27T20:39:26Z
dc.date.issued2003-05-19en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractAminoterminal portion of pro-brain natriuretic peptide (NT-proBNP) appears to be useful in the screening, diagnosis and prognosis of left ventricular dysfunction and congestive heart failure. The purpose of this study was to determine the values of serum NT-proBNP in normal Thai subjects compared with subjects from other countries. The design is a cross sectional study. The authors enrolled 243 consecutive healthy subjects (134 males and 109 females) from the checkup department of Bangkok Hospital for NT-proBNP measurement. The serum fraction was measured for NT-proBNP concentration by using Elecsys 2010 (Roche Diagnostics, Switzerland). The concentrations of NT-proBNP in normal Thai subjects were 33.30 +/- 35.43 pg/ml. The NT-proBNP levels increased with age (age < or = 50 years = 27.56 + 28.77 pg/ml and age > 50 years = 47.20 +/- 45.18 pg/ml, p < 0.001). Females usually have higher NT-proBNP than males (females = 40.42 +/- 31.59 pg/ml, males = 27.51 +/- 37.40 pg/ml, p = 0.0045). This study established the NT-proBNP concentrations in normal Thai subjects, which were not different from other studies. The authors suggested the normal cut-off values for subjects aged < or = 50 years should be 100 pg/ml and the normal cut-off values for subjects aged > 50 years should be 200 pg/ml. The NT-proBNP assay could be used as a rule out marker for heart failure in patients and may trigger further cardiac investigation.en_US
dc.description.affiliationDepartment of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.en_US
dc.identifier.citationLeowattana W, Sirithunyanont C, Sukumalchantra Y, Chaisupamonkollarp S, Watanawaroon S, Chivatanaporn B, Kangkagate C, Mahanonda N, Bhuripanyo K. Serum N-terminal pro-brain natriuretic peptide in normal Thai subjects. Journal of the Medical Association of Thailand. 2003 May; 86 Suppl 1(): S46-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43398
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshFemaleen_US
dc.subject.meshHeart Failure --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNatriuretic Peptide, Brain --blooden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshThailanden_US
dc.titleSerum N-terminal pro-brain natriuretic peptide in normal Thai subjects.en_US
dc.typeJournal Articleen_US
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