Time dependent immunomodulatory response of exogenous melatonin to killed Pasteurella multocida (P52 strain) vaccine in albino rats.

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dc.contributor.authorKorde, J Pen_US
dc.contributor.authorSrivastava, R Sen_US
dc.contributor.authorMishra, S Cen_US
dc.contributor.authorSharma, A Ken_US
dc.date.accessioned2005-04-21en_US
dc.date.accessioned2009-06-01T04:57:41Z
dc.date.available2005-04-21en_US
dc.date.available2009-06-01T04:57:41Z
dc.date.issued2005-04-21en_US
dc.description.abstractThe effect of time of administration of exogenous melatonin (M) at the rate of 100 microg/Kg BW of rat/day for 14 days on immunomodulation to killed Pasteurella multocida (P52 strain) vaccine (KPMV) was investigated in male albino rats during spring season with photoperiod of LL 13: DD 11 h and 25 +/- 2.5 degrees C air temperature and 70 +/- 4% relative humidity. The experiment was conducted at an altitude of 172 mts above mean sea level at latitude 28.20 degrees north, longitude 79.24 degrees east (Bareilly, U.P. India). The experimental animals were divided in-groups of 8 rats each, as KPMV + M at 4.00 h; KPMV + M at 16.00 h; KPMV and their controls M4, M16, PBS respectively. Humoral immune response was monitored at weekly intervals by an indirect ELISA and cellular immunity by leukocyte migration inhibition test (LMIT) and delayed type of hypersensitivity (DTH). As evinced by in-vitro assays and in-vivo protection studies, both humoral and cellular immune responses to KPMV were augmented in rats receiving exogenous melatonin at 4.00 h as compared to slightly reduced responses in rats treated with melatonin at 16.00 h. It was concluded that the circadian timings of melatonin administration modulate immune response in rats.en_US
dc.description.affiliationDivision of Physiology and Climatology, Indian Veterinary Research Institute, Izatnagar 243 122.en_US
dc.identifier.citationKorde JP, Srivastava RS, Mishra SC, Sharma AK. Time dependent immunomodulatory response of exogenous melatonin to killed Pasteurella multocida (P52 strain) vaccine in albino rats. Indian Journal of Physiology and Pharmacology. 2005 Apr; 49(2): 227-35en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106241
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdjuvants, Immunologic --administration & dosageen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntibody Formation --drug effectsen_US
dc.subject.meshBacterial Vaccines --immunologyen_US
dc.subject.meshCell Migration Inhibitionen_US
dc.subject.meshCircadian Rhythmen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshHypersensitivity, Delayed --immunologyen_US
dc.subject.meshImmunity, Cellular --drug effectsen_US
dc.subject.meshLeukocytes --immunologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMelatonin --administration & dosageen_US
dc.subject.meshPasteurella multocida --immunologyen_US
dc.subject.meshPhotoperioden_US
dc.subject.meshRatsen_US
dc.subject.meshSeasonsen_US
dc.subject.meshTime Factorsen_US
dc.titleTime dependent immunomodulatory response of exogenous melatonin to killed Pasteurella multocida (P52 strain) vaccine in albino rats.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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