Intravenous Iron sucrose and change in hemoglobin, ferritin, and oxidative stress markers among moderately anemic pregnant women attending a secondary care level Hospital in Northern India

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dc.contributor.authorJacob, OMen_US
dc.contributor.authorKant, Sen_US
dc.contributor.authorHaldar, Pen_US
dc.contributor.authorKaur, Ren_US
dc.contributor.authorDadhwal, Ven_US
dc.contributor.authorPrakash, Sen_US
dc.date.accessioned2020-04-10T03:46:51Z
dc.date.available2020-04-10T03:46:51Z
dc.date.issued2020-03
dc.description.abstractBackground: Intravenous iron is associated with oxidative stress, and very few studies have assessed change in oxidative stress markers post infusion. Objectives: The study aimed to measure the change in levels of hemoglobin (Hb), serum ferritin, and select oxidative stress markers (malondialdehyde [MDA], superoxide dismutase [SOD], and ferric reducing ability of plasma [FRAP]) 4 weeks following the administration of intravenous iron sucrose (IVIS) among moderately anemic pregnant women who were attending a secondary-level health-care facility, Haryana, North India. Methods: An observational study was conducted (May 2016 to Jan 2018) among pregnant women receiving intravenous iron sucrose i.e., IVIS (300 mg per dose) diluted in 300 mL of normal saline over 20� min and were followed up for a period of 4 weeks after the last dose of IVIS (end line). The study outcomes were measured in the levels of Hb, serum ferritin, MDA, SOD, and FRAP from the baseline to the end line. Results: The mean (95% confidence interval) change in the Hb and serum ferritin level 4 weeks after the last dose of IVIS was an increase of 2.5 (2.1�0) g/dL (P < 0.001) and 63.0 (44.7�.3) ng/mL (P < 0.001), respectively. There were no significant changes (baseline to end line) in mean (standard deviation [SD]) MDA level and mean (SD) FRAP level. The mean (SD) SOD level declined significantly (2.2 [0.4] U/mL to 1.6 [0.5] U/mL [P < 0.001]). No life-threatening adverse events were encountered during the study. Conclusion: IVIS was well tolerated and effective in treating moderate anemia in pregnancy. Body iron store was replenished following IVIS administration. There was no increase in oxidative stress following IVIS therapy.en_US
dc.identifier.affiliationsJunior Resident, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsProfessor and Head, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Obstetrics and Gynecology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsAssociate Professor, Department of Laboratory Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationJacob OM, Kant S, Haldar P, Kaur R, Dadhwal V, Prakash S. Intravenous Iron sucrose and change in hemoglobin, ferritin, and oxidative stress markers among moderately anemic pregnant women attending a secondary care level Hospital in Northern India. Indian Journal of Public Health. 2020 Mar; 64(1): 11-16en_US
dc.identifier.issn0019-557X
dc.identifier.issn2229-7693
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/198192
dc.languageenen_US
dc.publisherIndian Public Health Associationen_US
dc.relation.issuenumber1en_US
dc.relation.volume64en_US
dc.source.urihttps://dx.doi.org/10.4103/ijph.IJPH_464_18en_US
dc.subjectAnemiaen_US
dc.subjectintravenous iron sucroseen_US
dc.subjectiron sucroseen_US
dc.subjectoxidative stressen_US
dc.subjectpregnancyen_US
dc.titleIntravenous Iron sucrose and change in hemoglobin, ferritin, and oxidative stress markers among moderately anemic pregnant women attending a secondary care level Hospital in Northern Indiaen_US
dc.typeJournal Articleen_US
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