Correlation between susceptibility of Mycobacterium tuberculosis by microtiter plate alamar blue assay and clinical outcomes.

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dc.contributor.authorSungkanuparph, Somnueken_US
dc.contributor.authorPracharktam, Roongnapaen_US
dc.contributor.authorThakkinstian, Ammarinen_US
dc.contributor.authorBuabut, Benjamasen_US
dc.contributor.authorKiatatchasai, Wiphaweeen_US
dc.date.accessioned2009-05-27T20:50:08Z
dc.date.available2009-05-27T20:50:08Z
dc.date.issued2002-07-26en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractA rapid, inexpensive, and reliable antimycobacterial susceptibility assay is needed to effectively deal with the increasing prevalence of resistant strains of M. tuberculosis in Thailand. The microtiter plate Alamar blue assay (MABA) appears to be promising but requires additional data regarding correlation with clinical outcome. The correlation between the susceptibility by MABA and clinical outcomes was studied. There were 123 specimens obtained from extra-pulmonary sites of 108 patients at Ramathibodi Hospital in 1999. The authors found that susceptibility of M. tuberculosis isolates by the MABA correlated with the clinical outcome; patients with isolates sensitive to isoniazid, rifampicin, and ethambutol had a better clinical outcome than patients with isolates resistant to at least one of these drugs (p=0.004). Studies to determine this correlation in pulmonary tuberculosis are still needed.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationSungkanuparph S, Pracharktam R, Thakkinstian A, Buabut B, Kiatatchasai W. Correlation between susceptibility of Mycobacterium tuberculosis by microtiter plate alamar blue assay and clinical outcomes. Journal of the Medical Association of Thailand. 2002 Jul; 85(7): 820-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/43721
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAntitubercular Agents --therapeutic useen_US
dc.subject.meshBiological Assay --methodsen_US
dc.subject.meshColoring Agentsen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHumansen_US
dc.subject.meshMycobacterium tuberculosis --drug effectsen_US
dc.subject.meshOutcome Assessment (Health Care)en_US
dc.subject.meshOxazinesen_US
dc.subject.meshTuberculosis --drug therapyen_US
dc.subject.meshXanthenesen_US
dc.titleCorrelation between susceptibility of Mycobacterium tuberculosis by microtiter plate alamar blue assay and clinical outcomes.en_US
dc.typeJournal Articleen_US
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