L-asparaginase related hyperglycemia.

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dc.contributor.authorIyer, R Sen_US
dc.contributor.authorRao, S Ren_US
dc.contributor.authorPai, Sen_US
dc.contributor.authorAdvani, S Hen_US
dc.contributor.authorMagrath, I Ten_US
dc.date.accessioned2009-05-28T07:05:06Z
dc.date.available2009-05-28T07:05:06Z
dc.date.issued1993-06-01en_US
dc.description.abstractL-asparaginase is a valuable chemotherapeutic agent used in the induction of remission and improvement of long term survival in patients with acute lymphoblastic leukemia. Hyperglycemia is a well known side effect of L-asparaginase. Fourteen patients developed hyperglycemia during induction therapy of acute lymphoblastic leukemia with L-asparaginase, prednisolone, vincristine and daunorubicin. Hyperglycemia was observed after a mean of five doses of L-asparaginase (range 2-10). Seven of fourteen patients had neutropenic related infective episodes. Hyperglycemia resolved in all patients within 12 days (range 4-25) and two patients died of neutropenic septicemia. During reinduction therapy with the same drugs, only one out of ten patients developed hyperglycemia E-coli-L-asparaginase was replaced by Erwinia asparaginase in two patients one of who had recrudescence on further therapy. Close monitoring during L-asparaginase therapy for hyperglycemia will enable prompt recognition and early correction and prevent delay in therapy of acute lymphoblastic leukemia.en_US
dc.description.affiliationDepartment of Medical Oncology, Tata Memorial Hospital, Bombay, India.en_US
dc.identifier.citationIyer RS, Rao SR, Pai S, Advani SH, Magrath IT. L-asparaginase related hyperglycemia. Indian Journal of Cancer. 1993 Jun; 30(2): 72-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/50835
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAsparaginase --adverse effectsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperglycemia --chemically induceden_US
dc.subject.meshMaleen_US
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma --drug therapyen_US
dc.titleL-asparaginase related hyperglycemia.en_US
dc.typeJournal Articleen_US
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