Effect of doxorubicin on the intestinal membranes in rats—Influence of α-tocopherol administration.

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dc.contributor.authorGeetha, A
dc.contributor.authorSankar, R
dc.contributor.authorMarar, Thankamani
dc.contributor.authorDevi, C S Shyamala
dc.date.accessioned2015-07-28T08:30:25Z
dc.date.available2015-07-28T08:30:25Z
dc.date.issued1990-03
dc.description.abstractThe effect of α-tocopherol on doxorubicin induced changes in intestinal brush border and basolateral membranes were studied in rats. Rats were treated with doxorubicin (2·5 mg/kg body wt.), intravenously, weekly for 8 weeks. α-Tocopherol (400 mg/kg body wt.) was given orally, daily for 2 months. Intestinal basolateral membrane bound ATPases and brush border membrane bound alkaline phosphatase activities were found to be decreased significantly in doxorubicin treated rats. The lipid peroxide level was found to be elevated with a significant depletion in membrane sulphydryl groups. In α-tocopherol coadministered animals, the enzyme activities were found to be restored with concomitant reduction in lipid peroxide levels and an increase in the membrane sulphydryl groups. The membrane cholesterol and phospholipid levels which were altered in doxorubicin treated animals were found to be maintained significantly. The results are discussed with reference to the effect of α-tocopherol on lipid peroxidation and membrane sulphydryl groups.en_US
dc.identifier.citationGeetha A, Sankar R, Marar Thankamani, Devi C S Shyamala. Effect of doxorubicin on the intestinal membranes in rats—Influence of α-tocopherol administration. Journal of Biosciences. 1990 Mar; 15(1): 31-36.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/160768
dc.language.isoenen_US
dc.source.urihttps://www.ias.ac.in/jarch/jbiosci/15/31-36.pdfen_US
dc.subjectDoxorubicinen_US
dc.subjectintestineen_US
dc.subjectbasolateral membraneen_US
dc.subjectbrush border membraneen_US
dc.subjectATPasesen_US
dc.subjectalkaline phosphataseen_US
dc.subjectsulphydryl groupsen_US
dc.subjectα-tocopherolen_US
dc.subjectantioxidanten_US
dc.titleEffect of doxorubicin on the intestinal membranes in rats—Influence of α-tocopherol administration.en_US
dc.typeArticleen_US
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