Composition of gallstones and sequential events in biliary lithogenesis--is it different in south India compared to north?

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dc.contributor.authorAmin, A Men_US
dc.contributor.authorAnanthakrishnan, Nen_US
dc.contributor.authorNambinarayanan, T Ken_US
dc.date.accessioned2000-09-24en_US
dc.date.accessioned2009-05-30T18:17:32Z
dc.date.available2000-09-24en_US
dc.date.available2009-05-30T18:17:32Z
dc.date.issued2000-09-24en_US
dc.description.abstractAIMS: This study was carried out to determine the gross type and composition of gallstones from South India in order to compare it with published results from the North to see whether the sequential events in biliary lithogenesis are different in these two geographical areas. MATHODOLOGY: A total of 76 stones collected from various hospitals in South India including JIPMER were analysed using X-ray crystallography. Patient characteristics were recorded. Gross typing was done according to Bockus' morphological criteria. RESULTS: Patients with gallstones in South India were found to be older in age with near equal gender distribution. Pigment calcium stones accounted for 56.5%, pigment stones for 17.2% and mixed stones for 14.2% of gallstones. Bilirubin and its salts were the most frequently identified class of compounds by crystallography. Analysis of gallstones layer by layer revealed equal distribution of bilirubin compounds between the centre and outer layers except crystalline bilirubin which was found only in outer layers. Vaterite, a polymorph of calcium carbonate was found in the nucleus, whereas vaterite and aragonite were found in the outer layers. Combination of anhydrous cholesterol and cholesterol II were found in the nucleus. Epitaxial relationship were found to hold good except for vaterite and aragonite. CONCLUSION: Gallstones from South India are probably due to infection rather than supersaturation as evidenced by predominance of pigment calcium stones and various types of bilirubin and calcium carbonate compounds. Vaterite is important for nucleation. Further growth of stones is influenced by epitaxial relationship. These findings are dissimilar to that reported from North India indicating a different stimulus for stone precipitation in these two areas.en_US
dc.description.affiliationDepartment of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondichery-605006.en_US
dc.identifier.citationAmin AM, Ananthakrishnan N, Nambinarayanan TK. Composition of gallstones and sequential events in biliary lithogenesis--is it different in south India compared to north? Journal of the Association of Physicians of India. 2000 Sep; 48(9): 885-90en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/85699
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshBilirubin --analysisen_US
dc.subject.meshCalcium Carbonate --analysisen_US
dc.subject.meshCholelithiasis --chemistryen_US
dc.subject.meshCholesterol --analysisen_US
dc.subject.meshCrystallography, X-Rayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.titleComposition of gallstones and sequential events in biliary lithogenesis--is it different in south India compared to north?en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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