Antiovulatory and Estrogenic Activity of Stem of Musa paradisiaca in Female Albino Rats.
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Date
2013-08
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Abstract
Our aim is to evaluate the effect of petroleum ether, chloroform, acetone, ethanol and aqueous extracts of stem of
Musa paradisiaca Linn (Musaceae) on the estrous cycle and to identify the estrogenic activity of most active
ethanol extract in female albino rats. Plant extracts were tested for antifertility activity in female albino rats at
two dose level 250 and 500 mg/kg respectively. The effective ethanol extract were further studied on estrogenic
activity in rats. Histological studies of the uterus were carried out to confirm their estrogenic activity. The result
of study revealed that the treatment of rats with extract of M. paradisiaca Linn at a dose of 250 and 500 mg/kg
body weight for five days cause a prolonged diestrous stage of the estrous cycle with consequent temporary
inhibition of ovulation. The ethanol extract was most effective in interrupting the normal cycle of rats (P<
0.05<0.01<0.001). This later exhibited prolonged diestrous stage of the estrous cycle with consequent temporary
inhibition of ovulation. The antiovulatory activity was reversible on discontinuation of treatment. The ethanol
extract showed significant estrogenic and antiestrogenic activity. All findings suggest that the antifertility activity
of ethanol extract of M. paradisiaca Linn.
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Keywords
Antiovulatory activity, Estrogenic Activity, Musa paradisica
Citation
Soni Priyanka, Siddiqui Anees Ahmad, Dwivedi Jaya, Soni Vishal. Antiovulatory and Estrogenic Activity of Stem of Musa paradisiaca in Female Albino Rats. Journal of Applied Pharmaceutical Science. 2013 Aug; 3(8): 102-106.