Assessing the role of subconjunctival versus intrascleral application of mitomycin C in high-risk trabeculectomies.

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dc.contributor.authorAgarwal, H Cen_US
dc.contributor.authorSaigal, Den_US
dc.contributor.authorSihota, Ren_US
dc.date.accessioned2001-06-12en_US
dc.date.accessioned2009-05-29T08:48:44Z
dc.date.available2001-06-12en_US
dc.date.available2009-05-29T08:48:44Z
dc.date.issued2001-06-12en_US
dc.description.abstractPURPOSE: To compare the efficacy and safety of subconjunctival and intrascleral applications of mitomycin C (MMC) in trabeculectomy for high-risk glaucomas. METHODOLOGY: A randomized prospective clinical study was conducted on 41 consecutive eyes with a high risk of glaucoma surgery failure. Patients were randomized to trabeculectomy and application of subconjunctival MMC or to trabeculectomy and application of intrascleral MMC. MMC solution 0.2 mg/ml was applied for 3 minutes under the conjunctival flap overlying the proposed site of trabeculectomy in Group I (n=21), or intrasclerally under the superficial scleral flap in Group II (n=20) RESULTS: After a follow-up of one year, the intraocular pressure (IOP) decreased from a mean basal IOP of 33.0 +/- 8.4 mm Hg to 12.56 +/- 2.54 mm Hg in Group I and from 30.9 +/- 6.6 mm Hg to 11.6 +/- 2.21 mm Hg in Group II. The IOP was 6-21 mmHg, without medication, in 90.5 % of the eyes in Group I and 75 % of the eyes Group II. Ocular hypotony, hypotony maculopathy, choroidal detachment and a shallow anterior chamber were more frequent with the intrascleral application of MMC during trabeculectomy, but the difference was not statistically significant. The overall success of the surgery at one year, i.e., achieving an IOP of 6-21 mmHg and a stable vision, (reduction in visual acuity of < or = 2 lines), was 90.5% in Group I and 75 % in Group II. CONCLUSION: No significant difference was seen in overall success or complication between subconjunctival and intrascleral application of MMC-augmented trabeculectomies in glaucomatous eyes at high risk of surgical failure.en_US
dc.description.affiliationGlaucoma Service, Dr. R.P. Centre for Ophthalmic Sciences, AIIMS, New Delhi, India.en_US
dc.identifier.citationAgarwal HC, Saigal D, Sihota R. Assessing the role of subconjunctival versus intrascleral application of mitomycin C in high-risk trabeculectomies. Indian Journal of Ophthalmology. 2001 Jun; 49(2): 91-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/70897
dc.language.isoengen_US
dc.source.urihttps://www.ijo.inen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAlkylating Agents --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlaucoma --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshIntraocular Pressureen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMitomycin --administration & dosageen_US
dc.subject.meshPostoperative Complicationsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSclera --surgeryen_US
dc.subject.meshTrabeculectomy --methodsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshVisual Acuityen_US
dc.titleAssessing the role of subconjunctival versus intrascleral application of mitomycin C in high-risk trabeculectomies.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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