Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.

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dc.contributor.authorMukhopadhyay, Sanjuktaen_US
dc.contributor.authorGhosh, Disharien_US
dc.contributor.authorChatterjee, Aparajitaen_US
dc.contributor.authorSinha, Sancharien_US
dc.contributor.authorTripathy, Smritiratanen_US
dc.contributor.authorChandra, Amar Ken_US
dc.date.accessioned2005-07-31en_US
dc.date.accessioned2009-06-01T05:39:04Z
dc.date.available2005-07-31en_US
dc.date.available2009-06-01T05:39:04Z
dc.date.issued2005-07-31en_US
dc.description.abstractNitrate is a wide spread contaminant of ground and surface water. The source of nitrate in the ground water may be from run off or seepage from fertilized soil, municipal or industrial waste water, land fills, septic system, urban drainage or decaying plants. Human and animal systems are affected severely on nitrate exposure. The study was to investigate the effect of dietary nitrate exposure on the thyroid status along with the state of iodine nutrition. Rats were fed diet containing 3% potassium nitrate (KNO3) for 4 weeks and then thyroid status was evaluated by thyroid gland weight, urinary iodine excretion pattern, thyroid peroxidase (TPO) activity, serum levels of total thyroxine (T4), triiodothyronine (T3) and thyroid stimulating hormone (TSH) concentrations. In nitrate treated animals, the weight of thyroid gland was increased significantly (P<0.001) while thyroid peroxidase activity (P<0.01), serum T4 (P<0.01) and serum T3 levels (P<0.001) were reduced; but serum TSH level was increased (P<0.001) along with slightly elevated iodine excretion level (P<0.001) in comparison to control animals. The overall results indicated the development of a relative state of functional hypothyroidism with enlarged thyroid after nitrate exposure. This study can explain a part for the persistence of residual goitre in the post-salt iodization phase.en_US
dc.description.affiliationEndocrinology and Reproductive Physiology Laboratory, Department of Physiology, University of Calcutta, University College of Science and Technology, Kolkata.en_US
dc.identifier.citationMukhopadhyay S, Ghosh D, Chatterjee A, Sinha S, Tripathy S, Chandra AK. Evaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant. Indian Journal of Physiology and Pharmacology. 2005 Jul-Sep; 49(3): 284-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106777
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBody Weighten_US
dc.subject.meshDieten_US
dc.subject.meshEnvironmental Pollutants --toxicityen_US
dc.subject.meshGoiter --etiologyen_US
dc.subject.meshHypothyroidism --blooden_US
dc.subject.meshIodide Peroxidase --metabolismen_US
dc.subject.meshIodine --physiologyen_US
dc.subject.meshNitrates --administration & dosageen_US
dc.subject.meshOrgan Sizeen_US
dc.subject.meshPotassium Compounds --administration & dosageen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshThyroid Gland --drug effectsen_US
dc.subject.meshThyrotropin --blooden_US
dc.subject.meshThyroxine --blooden_US
dc.subject.meshTriiodothyronine --blooden_US
dc.subject.meshWater Pollutants, Chemicalen_US
dc.titleEvaluation of possible goitrogenic and anti-thyroidal effect of nitrate, a potential environmental pollutant.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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