Clinical, biochemical & cytomorphologic study on Hashimoto’s thyroiditis.

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dc.contributor.authorThomas, Tina
dc.contributor.authorSreedharan, Suja
dc.contributor.authorKhadilkar, Urmila N
dc.contributor.authorDeviprasad, D
dc.contributor.authorKamath, M Panduranga
dc.contributor.authorBhojwani, Kiran M
dc.contributor.authorAlva, Arathi
dc.date.accessioned2015-06-25T09:10:13Z
dc.date.available2015-06-25T09:10:13Z
dc.date.issued2014-12
dc.description.abstractBackground & objectives: Despite, the extensive salt iodization programmes implemented in India, the prevalence of goiter has not reduced much in our country. The most frequent cause of hypothyroidism and goiter in iodine sufficient areas is Hashimoto’s thyroiditis (HT). This study records the clinical presentation, biochemical status, ultrasonographic picture and cytological appearance of this disease in a coastal endemic zone for goiter. Methods: Case records of patients with cytological diagnosis of HT were studied in detail, with reference to their symptoms, presence of goiter, thyroid function status, antibody levels and ultrasound picture. Detailed cytological study was conducted in selected patients. Results: A total of 144 patients with cytological proven HT/lymphocytic thyroiditis were studied. Ninety per cent of the patients were females and most of them presented within five years of onset of symptoms. Sixty eight per cent patients had diffuse goiter, 69 per cent were clinically euthyroid and 46 per cent were biochemically mildly hypothyroid. Antibody levels were elevated in 92.3 per cent cases. In majority of patients the sonographic picture showed heterogeneous echotexture with increased vascularity. Cytological changes were characteristic. Interpretation & conclusions: our study showed predominance of females in the study population in 21-40 yr age group with diffuse goiter. We suggest that in an endemic zone for goiter, all women of the child bearing age should be screened for HT.en_US
dc.identifier.citationThomas Tina, Sreedharan Suja, Khadilkar Urmila N, Deviprasad D, Kamath M Panduranga, Bhojwani Kiran M, Alva Arathi. Clinical, biochemical & cytomorphologic study on Hashimoto’s thyroiditis. Indian Journal of Medical Research. 2014 Dec; 140 (6): 729-735.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158368
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365346/?report=classicen_US
dc.subjectantithyroid antibodyen_US
dc.subjectcytologyen_US
dc.subjectFNAen_US
dc.subjectgoiteren_US
dc.subjectHashimoto’s thyroiditisen_US
dc.subjecthypothyroidismen_US
dc.subjectlymphocytic infiltrationen_US
dc.subject.meshAdult
dc.subject.meshBiopsy, Fine-Needle
dc.subject.meshCarbimazole --administration & dosage
dc.subject.meshCytodiagnosis
dc.subject.meshFemale
dc.subject.meshGoiter --diagnosis
dc.subject.meshGoiter --drug therapy
dc.subject.meshGoiter --pathology
dc.subject.meshHashimoto Disease --diagnosis
dc.subject.meshHashimoto Disease --drug therapy
dc.subject.meshHashimoto Disease --pathology
dc.subject.meshHumans
dc.subject.meshIodine --metabolism
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.titleClinical, biochemical & cytomorphologic study on Hashimoto’s thyroiditis.en_US
dc.typeArticleen_US
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