An investigation on in vivo allergenicity of Artemisia annua leaves and stems.

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dc.contributor.authorLeng, Xen_US
dc.contributor.authorYe, S Ten_US
dc.date.accessioned2009-05-27T17:07:13Z
dc.date.available2009-05-27T17:07:13Z
dc.date.issued1987-12-01en_US
dc.descriptionPublished by the Allergy and Immunology Society of Thailand.en_US
dc.description.abstractPollen of Artemisia annua is considered to be one of the most important allergens in autumnal hay fever in China, just as ragweed is in North America. In order to clarify the allergenicity of non-pollen containing components of the plant, Artemisia annua leaves and stems were collected and extracted before pollination time. The extracts of these pollen-free plant components were studied for allergenic activities using skin prick tests, intradermal tests, intranasal challenge and bronchial provocation tests. In 52 subjects sensitive to Artemisia pollen, 92.3% gave positive responses in skin prick tests, 100% gave positive responses in intradermal tests, 66.7% gave positive responses in intranasal challenge and 59.3% gave positive responses in bronchial provocation tests. Negative results to skin prick tests, intradermal tests and bronchial provocation tests were revealed in 30 seasonal asthmatics who gave negative responses to the pollen skin tests. Strict placebo control showed all negative tests in non-atopic adult human volunteers. We concluded that pollen-free plant extracts did have in vivo allergenic activities. Analysis of the plant allergenic components in vitro will be the subject of further studies.en_US
dc.description.affiliationDepartment of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing.en_US
dc.identifier.citationLeng X, Ye ST. An investigation on in vivo allergenicity of Artemisia annua leaves and stems. Asian Pacific Journal of Allergy and Immunology. 1987 Dec; 5(2): 125-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/36494
dc.language.isoengen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsthma --etiologyen_US
dc.subject.meshBronchial Provocation Testsen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNasal Provocation Testsen_US
dc.subject.meshPlant Extracts --immunologyen_US
dc.subject.meshPlants --immunologyen_US
dc.subject.meshPollen --immunologyen_US
dc.subject.meshRhinitis, Allergic, Seasonal --etiologyen_US
dc.subject.meshSkin Testsen_US
dc.titleAn investigation on in vivo allergenicity of Artemisia annua leaves and stems.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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