Natural history of subclinical hypothyroidism in diabetes mellitus: a prospective observational study

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dc.contributor.authorSingh, SKen_US
dc.contributor.authorSingh, Ren_US
dc.contributor.authorBedi, Sen_US
dc.contributor.authorPandey, AKen_US
dc.contributor.authorTiwari, Aen_US
dc.contributor.authorRai, PK.en_US
dc.date.accessioned2025-05-09T07:20:41Z
dc.date.available2025-05-09T07:20:41Z
dc.date.issued2024-12
dc.description.abstractBackground: The natural course of subclinical hypothyroidism (SCH) is variable. Several studies have shown that not all SCH progresses to overt hypothyroidism (OH). Little data are available regarding the natural course of SCH in diabetes mellitus (DM). We aimed to investigate the natural course of SCH in DM patients. Methods: A total of 118 patients with SCH (52 with DM and 66 without DM) were enrolled in this prospective observational study. Anthropometric, thyroid hormone and Anti-thyroid peroxidase (TPO) antibody (Ab) level were measured at baseline. Thyroid hormone levels were also estimated at 6 month and 12 months. Result: The majority of the patients, 76(61.86%), remained with SCH, 21(17.8%) progressed to OH and 24 (20.83%) reverted to normal. The rate of progression to OH (DM: 7.69% vs non-DM: 25.76%) was significantly lower in patients with diabetes than in those without. Multivariate logistic regression analysis showed that the risk factors for progression to OH were the glycemic status and thyroid autoantibody. Conclusion: The present study suggests that patient with SCH have variable disease courses. Glycemic status and autoimmunity are the two most powerful predictors of OH. DM protects the progression to OH whereas thyroid autoantibody increases the risk of progression to OH. We recommend a more aggressive follow up for thyroid autoantibody positive and non-diabetic patients.en_US
dc.identifier.affiliationsDepartment of Endocrine, Endocrine Clinic, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrine, Endocrine Clinic, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrine, Lucknow Endocrine Diabetes and Thyroid Clinic, Vivek Khand, Gomti Nagar, Lucknow, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Endocrine, Diabetes and Endocrine care Superspeciality clinic, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Opal Hospital, Varanasi, Uttar Pradesh, Indiaen_US
dc.identifier.citationSingh SK, Singh R, Bedi S, Pandey AK, Tiwari A, Rai PK.. Natural history of subclinical hypothyroidism in diabetes mellitus: a prospective observational study . International Journal of Advances in Medicine. 2024 Dec; 11(6): 584-590en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242800
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber6en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2349-3933.ijam20243062en_US
dc.subjectDiabetes mellitusen_US
dc.subjectOvert hypothyroidismen_US
dc.subjectSubclinical hypothyroidismen_US
dc.subjectThyroid autoimmunityen_US
dc.titleNatural history of subclinical hypothyroidism in diabetes mellitus: a prospective observational studyen_US
dc.typeJournal Articleen_US
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