Effects of iron therapy on cognition in anemic school going boys.

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dc.contributor.authorBandhu, Ren_US
dc.contributor.authorShankar, Nen_US
dc.contributor.authorTandon, O Pen_US
dc.contributor.authorMadan, Nen_US
dc.date.accessioned2003-07-16en_US
dc.date.accessioned2009-06-01T05:54:29Z
dc.date.available2003-07-16en_US
dc.date.available2009-06-01T05:54:29Z
dc.date.issued2003-07-16en_US
dc.description.abstractThe present study was conducted on 18 anemic and 34 control subjects (mean age 9.26 +/- 0.26 years) to observe the effect of anemia on cognition and to see effect of 3 months of iron therapy on it. Anemia was defined on the basis of hematological values and peripheral smear examinations. Cognitive data consisted of the recording of the P300 wave of Auditory Event Related Potentials (AERP), Ravens Progressive Matrices Test (RPMT), and Digit Span Attention Test (DSAT) under standard test conditions. RPMT scores were then converted to the intelligence quotient (IQ) scores for comparison. Both anemic and control boys were dewormed after recording pretreatment values and then anemic boys were given iron therapy for 3 months, after which the recordings were taken again. Pretreatment, anemic boys showed significantly lower hematological values, delayed P300 latency, and lower RPMT scores as compared to controls. Post therapy the hematological profile of anemic boys though significantly improved as compared to the pretreatment values, was still significantly lower than that of control boys. The P300 latency values of anemic boys showed improvement but were still significantly delayed than the control group. RPMT values and derived IQ scores of anemic boys were similar to control boys after therapy suggesting that though the 3 months iron therapy regime resulted in improvement in psychometric cognitive tests in anemic boys, the basic P300 defects persisted. This suggests that the P300 component of AERP in anemic children is relatively refractory to 3 months of iron therapy.en_US
dc.description.affiliationDepartment of Physiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, Delhi 110 095. dbmi@ucms.ernet.inen_US
dc.identifier.citationBandhu R, Shankar N, Tandon OP, Madan N. Effects of iron therapy on cognition in anemic school going boys. Indian Journal of Physiology and Pharmacology. 2003 Jul; 47(3): 301-10en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106976
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnemia --drug therapyen_US
dc.subject.meshAttention --drug effectsen_US
dc.subject.meshBlood Cell Counten_US
dc.subject.meshChilden_US
dc.subject.meshCognition --drug effectsen_US
dc.subject.meshEvent-Related Potentials, P300 --drug effectsen_US
dc.subject.meshEvoked Potentials, Auditory --drug effectsen_US
dc.subject.meshHemoglobins --analysisen_US
dc.subject.meshHumansen_US
dc.subject.meshIron --therapeutic useen_US
dc.subject.meshMaleen_US
dc.subject.meshNeuropsychological Testsen_US
dc.subject.meshPsychometricsen_US
dc.titleEffects of iron therapy on cognition in anemic school going boys.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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