Clinical profile of hepatorenal syndrome: a prospective study.
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Date
2016-07
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Abstract
Background: Hepatorenal syndrome is the development of renal
failure in patients with advanced liver cirrhosis, occasionally
fulminant hepatitis, who have portal hypertension and ascitis in
the absence of some other kidney disease.
Objective: To study the clinical profile of hepatorenal syndrome.
Methods: All patients of chronic liver disease with renal
involvement were studied and patients fulfilling the criteria of
hepatorenal syndrome were recruited in the study. The etiology,
clinical presentation, morbidity and outcome of patients were
recorded. Various variables were studied between survivor group
and non survivor group to detect possible predictors of non
survival in hepatorenal syndrome. The data was analyzed using
SPSS software.
Results: 42 patients of hepatorenal syndrome were clinically
evaluated. 95% were males and 5% females with mean age of
50.29±8.87 in survivor group and 45.92±10.1 in non survivor
group. High level of serum bilirubin, hepatic encephalopathy,
decreased level of albumin, hyponatremia and coagulopathy
were significant in non survivor group as compared to survivor
group.
Conclusion: The poor prognostic factors were found to be ascites,
severe jaundice, hepatic encephalopathy, alcohol abuse,
hypoalbuminemia, progressive renal failure and child pugh score
greater than 10. Thus hepatorenal syndrome is decompensated cirrhosis which needs judicious treatment
especially using terlipressin and albumin.
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Keywords
Hepatorenal syndrome, profile, jaundice, child pugh score, ascitis, albumin
Citation
Singh H, Kumar R, Sandhu J S. Clinical profile of hepatorenal syndrome: a prospective study. International Journal of Medical and Dental Sciences. 2016 July; 5(2): 1241-1246.