Posterior corneal morphological changes in primary congenital glaucoma

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dc.contributor.authorGupta, Shikhaen_US
dc.contributor.authorMahalingam, Karthikeyanen_US
dc.contributor.authorSingh, Abhisheken_US
dc.contributor.authorSelvan, Harathyen_US
dc.contributor.authorSomarajan, Bindu Ien_US
dc.contributor.authorGupta, Vineyen_US
dc.date.accessioned2023-08-25T06:33:45Z
dc.date.available2023-08-25T06:33:45Z
dc.date.issued2022-07
dc.description.abstractPurpose: To compare posterior corneal morphology between older treated and younger untreated children with primary congenital glaucoma (PCG) using anterior segment optical coherence tomography (ASOCT) and intraoperative OCT (iOCT), respectively. Methods: In this comparative study, ASOCT of older PCG children were compared with iOCT of younger untreated PCG patients. Differences between the two groups with respect to posterior corneal morphology were studied. Results: Observed morphological patterns within posterior cornea in older treated (age: 72–300 months) children (87 eyes) included Descemet’s membrane (DM) excrescences (70%), thickened DM (35%), intracameral twin protuberances (92%), and DM detachment (26%). Changes within pre?Descemet’s layer (PDL) (28%) included thickening, breaks, and detachments. Extent of Haab’s striae was associated with thickness of DM/PDL complex (P = 0.008) when analyzed in the treated group. In contrast, in the untreated group (n = 53 eyes, age 1–63 months), posterior corneal changes were limited to diffuse hyper?reflectivity of the DM/PDL complex, with absence of DM tears. Conclusion: Posterior cornea thickens and Haab’s striae become more circumscribed in eyes of older treated children compared to untreated PCG eyes, probably reflecting a healing response of posterior cornea over time.en_US
dc.identifier.affiliationsGlaucoma Services, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationGupta Shikha, Mahalingam Karthikeyan, Singh Abhishek, Selvan Harathy, Somarajan Bindu I, Gupta Viney. Posterior corneal morphological changes in primary congenital glaucoma. Indian Journal of Ophthalmology. 2022 Jul; 70(7): 2571-2577en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224432
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber7en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_317_22en_US
dc.subjectAnterior Segment Optical Coherence Tomographyen_US
dc.subjectcongenital glaucomaen_US
dc.subjectDescemet’s membraneen_US
dc.subjectHaab’s striaeen_US
dc.subjectpre?Descemet’s membraneen_US
dc.titlePosterior corneal morphological changes in primary congenital glaucomaen_US
dc.typeJournal Articleen_US
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