Spectrophotometric simultaneous determination of hydrochlorothiazide and telmisartan in combined dosage form.
Loading...
Date
2011-03
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Simple, sensitive, specific and economic spectrophotometric method was developed and validated
for simultaneous quantitation of Hydrochlorothiazide and Telmisartan in tablet dosage form. New
method based on the simultaneous estimation of drugs in a binary mixture without previous
separation was developed. In simultaneous equation method, Hydrochlorothiazide and Telmisartan
were quantified using their absorptivity values of at selected wavelengths, viz., 273 nm and 295
nm respectively. The accuracy and reproducibility of the proposed method was statistically
validated by recovery studies. The simultaneous equation method permits simple, rapid and direct
determination of Hydrochlorothiazide and Telmisartan in commercially available tablet dosage
form without previous separations and can therefore be used for routine analysis of both drugs in
quality control laboratories.
Description
Keywords
Telmisartan, Hydrochlorothiazide, Vierodt’s method
Citation
Gangola Rekha, Kaushik Sunil, Sharma Paras. Spectrophotometric simultaneous determination of hydrochlorothiazide and telmisartan in combined dosage form. Journal of Applied Pharmaceutical Science. 2011 Mar; 1(1): 46-49.