Heat shock protein 90: the cancer chaperone.

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dc.contributor.authorNeckers, Lenen_US
dc.date.accessioned2007-04-31en_US
dc.date.accessioned2009-06-01T14:19:45Z
dc.date.available2007-04-31en_US
dc.date.available2009-06-01T14:19:45Z
dc.date.issued2007-04-31en_US
dc.description125 references.en_US
dc.description.abstractHeat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and function of a number of conditionally activated and/or expressed signalling proteins, as well as multiple mutated, chimeric, and/or over-expressed signalling proteins, that promote cancer cell growth and/or survival. Hsp90 inhibitors are unique in that, although they are directed towards a specific molecular target, they simultaneously inhibit multiple cellular signalling pathways. By inhibiting nodal points in multiple overlapping survival pathways utilized by cancer cells, combination of an Hsp90 inhibitor with standard chemotherapeutic agents may dramatically increase the in vivo efficacy of the standard agent. Hsp90 inhibitors may circumvent the characteristic genetic plasticity that has allowed cancer cells to eventually evade the toxic effects of most molecularly targeted agents. The mechanism-based use of Hsp90 inhibitors, both alone and in combination with other drugs, should be effective toward multiple forms of cancer. Further, because Hsp90 inhibitors also induce Hsf-1-dependent expression of Hsp70, and because certain mutated Hsp90 client proteins are neurotoxic, these drugs display ameliorative properties in several neurodegenerative disease models, suggesting a novel role for Hsp90 inhibitors in treating multiple pathologies involving neurodegeneration.en_US
dc.description.affiliationUrologic Oncology Branch, National Cancer Institute, Bethesda, MD 20892, USA. len@helix.nih.goven_US
dc.identifier.citationNeckers L. Heat shock protein 90: the cancer chaperone. Journal of Biosciences. 2007 Apr; 32(3): 517-30en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/110751
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents --pharmacologyen_US
dc.subject.meshHSP90 Heat-Shock Proteins --antagonists & inhibitorsen_US
dc.subject.meshHumansen_US
dc.subject.meshNeoplasms --drug therapyen_US
dc.titleHeat shock protein 90: the cancer chaperone.en_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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