Ascorbic acid irrigation during debridement decreased the colony count of Staphylococcus aureus and interleukin-6 blood count in grade ii open fracture of long bones

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dc.contributor.authorSuyasa, I. Ketuten_US
dc.contributor.authorAstawa, Putuen_US
dc.contributor.authorRidia, Mulyadien_US
dc.contributor.authorWibowo, Trimantoen_US
dc.date.accessioned2020-11-18T10:02:35Z
dc.date.available2020-11-18T10:02:35Z
dc.date.issued2020-09
dc.description.abstractBackground: Infection in open fractures is still a problem that cannot be fully managed. Various types of studies have been conducted to find an effective and efficient solution to wash open fracture wounds. This study compared the effectiveness of ascorbic acid irrigation in reduction of Staphylococcus aureus colony and interleukin-6 (IL-6) serum level as systemic inflammation marker in debridement procedure of grade II Gustilo-Anderson open fracture of long bones.Methods: This study was an experimental study with pre-post-test control group design. This study included 24 subjects aged 15-75 years old with Gustillo-Anderson type II open fractures which were divided into two groups. The treatment group had additional irrigation by using 10 mg/ml ascorbic acid solution during debridement, whereas the control group had debridement only without irrigation with ascorbic acid. The culture and colony count of Staphylococcus aureus and IL-6 serum level was obtained and measured before and after the treatment in both groups. Statistical analysis (Wilcoxon test) was performed to compare the difference of the two parameters (Δ colony count and Δ IL-6) before and after the treatment.Results: There were no significant difference in Δ colony count of Staphylococcus aureus (p=0.308) and ΔIL-6 serum level (p=0.239) between the control group and treatment group.Conclusions: Ascorbic acid irrigation was not proved to decrease the colony count of Staphylococcus aureus and IL-6 serum level in grade II open fracture of long bones.en_US
dc.identifier.affiliationsDepartment of Orthopaedics and Traumatology, Faculty of Medicine, Udayana University, Sanglah General Hospital, Udayana University, Bali, Indonesiaen_US
dc.identifier.citationSuyasa I. Ketut, Astawa Putu, Ridia Mulyadi, Wibowo Trimanto. Ascorbic acid irrigation during debridement decreased the colony count of Staphylococcus aureus and interleukin-6 blood count in grade ii open fracture of long bones. International Journal of Research in Medical Sciences. 2020 Sep; 8(9): 3194-3197en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212640
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber9en_US
dc.relation.volume8en_US
dc.source.urihttps://dx.doi.org/10.18203/2320-6012.ijrms20203666en_US
dc.subjectAscorbic aciden_US
dc.subjectInterleukin-6en_US
dc.subjectOpen fracturesen_US
dc.subjectStaphylococcus aureusen_US
dc.titleAscorbic acid irrigation during debridement decreased the colony count of Staphylococcus aureus and interleukin-6 blood count in grade ii open fracture of long bonesen_US
dc.typeJournal Articleen_US
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