Normal limits of 14C-urea breath test.

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dc.contributor.authorKaul, Aen_US
dc.contributor.authorBhasin, D Ken_US
dc.contributor.authorPathak, C Men_US
dc.contributor.authorRay, Pen_US
dc.contributor.authorVaiphei, Ken_US
dc.contributor.authorSharma, B Cen_US
dc.contributor.authorSingh, Ken_US
dc.date.accessioned1998-07-26en_US
dc.date.accessioned2009-06-04T04:51:22Z
dc.date.available1998-07-26en_US
dc.date.available2009-06-04T04:51:22Z
dc.date.issued1998-07-26en_US
dc.description.abstractBACKGROUND/AIMS: 14C-urea breath test has been widely used for diagnosis of Helicobacter pylori (H. pylori) infection. There is no general agreement on the cutoff values for determination of H. pylori negative subjects. We studied baseline values in subjects who were proved to be H. pylori negative and calculated the cutoff value of normalcy. A comparison of this test with other tests for diagnosis of H. pylori infection was also done. PATIENTS AND METHODS: 12 patients (mean age 34 +/- 14, range 22-65 years; 8 men) of non-ulcer dyspepsia were studied, who were proved to be H. pylori negative by rapid urease test, Gram's staining, histopathology and culture of gastric mucosal biopsies obtained four each from the antrum, body and fundus of the stomach. The controls included 12 patients (mean age 40 +/- 13, range 22-65 years, 9 men), who were positive for H. pylori on culture or combination of rapid urease test and histopathology or rapid urease test and Gram's stain. 14C-urea breath test was performed using 5 uCi of 14C-urea dissolved in 300 ml of water. Breath samples were collected once before ingestion of 14C urea and subsequently at 5, 15 and 30 minutes after ingestion and 14C-contents in the breath samples measured. Results were expressed as 14 CO2/mmol CO2 exhaled as percent of administered urea. RESULTS: The mean +/- SD 14-C value in H. pylori negative vs H. pylori positive patients at 5 minutes, 15 minutes and 30 minutes were found to be 0.003 +/- 0.003 vs 0.064 +/- 0.042 (p < 0.001), 0.002 +/- 0.001 vs 0.056 +/- 0.039 (p < 0.001) and 0.001 +/- 0.002 vs 0.041 +/- 0.026 (p < 0.001) respectively. The mean values of 14C-urea breath test were significantly lower in H. pylori negative patients as compared to H. pylori positive patients. Using receiver operating characteristic (ROC) analysis of the data, the cutoff values obtained were 0.01, 0.007 and 0.009 at 5 minutes, 15 minutes and 30 minutes respectively. CONCLUSIONS: 14C-urea breath test levels at 5, 15 and 30 minutes intervals are significantly lower in H. pylori negative patients as compared to H. pylori positive patients. This test has high sensitivity and specificity in detecting H. pylori infection.en_US
dc.description.affiliationDepartment of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh.en_US
dc.identifier.citationKaul A, Bhasin DK, Pathak CM, Ray P, Vaiphei K, Sharma BC, Singh K. Normal limits of 14C-urea breath test. Tropical Gastroenterology. 1998 Jul-Sep; 19(3): 110-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/125191
dc.language.isoengen_US
dc.source.urihttps://www.tropicalgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBreath Testsen_US
dc.subject.meshCarbon Radioisotopes --diagnostic useen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDiagnosis, Differentialen_US
dc.subject.meshDyspepsia --microbiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHelicobacter Infections --diagnosisen_US
dc.subject.meshHelicobacter pylori --isolation & purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshUrea --metabolismen_US
dc.titleNormal limits of 14C-urea breath test.en_US
dc.typeJournal Articleen_US
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