Prevalence of hepatitis B & C infections in prospective blood donors deferred due to history of jaundice

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dc.contributor.authorKhan, Mohd. Fawad Farooqen_US
dc.contributor.authorAfzal, Kamranen_US
dc.contributor.authorArif, S. H.en_US
dc.contributor.authorShahin, Shadmaen_US
dc.date.accessioned2023-08-19T04:52:30Z
dc.date.available2023-08-19T04:52:30Z
dc.date.issued2022-12
dc.description.abstractBackground & objectives: As per national guidelines, prospective blood donors with a history of jaundice of unknown cause are deferred permanently to prevent the transmission of hepatitis B and C. The validity of this guideline was tested by comparing prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice, with that of donors who were found fit. Methods: Blood samples of 212 consecutive donors (male, n=203) deferred due to a history of jaundice were studied for hepatitis B and C by rapid test kits as well as by chemiluminescence (n=115) or ELISA (n=97). Consecutive healthy donors (n=549; male, n=518) were also studied by ELISA (n=266) or chemiluminescence (n=283). Results: The cumulative prevalence detected by rapid test kit and ELISA/chemiluminescence tests of hepatitis B (n=10) and C (n=2) among donors deferred due to a history of jaundice (n=212) was 5.7 per cent [95% confidence interval (CI): 2.9, 9.9]. The prevalence of reactive results among healthy donors (n=549) by ELISA/chemiluminescence tests was 3.3 per cent (95% CI: 1.9, 5.2), which included hepatitis B (n=15) and hepatitis C (n=3) cases. Compared to healthy donors, the odds of seropositivity among jaundice-deferred donors was 1.7 (95% CI: 0.8, 3.6), P=0.15. For rapid test-negative deferred donors, the odds of seropositivity by ELISA/chemiluminescence declined to 0.4 (0.1, 1.5), P=0.19. Interpretation & conclusions: The prevalence rates of hepatitis B and C in prospective blood donors deferred due to a history of jaundice of unknown aetiology did not differ significantly from that in healthy donors. The current practice of permanently deferring such donors depletes valuable donor pool. A strategy of rejecting only those donors who are found reactive on pre-donation testing by rapid test needs further validation.en_US
dc.identifier.affiliationsDepartments ofen_US
dc.identifier.affiliationsBlood Banken_US
dc.identifier.affiliationsPediatricsen_US
dc.identifier.affiliationsPathology, Jawaharlal Nehru Medical College Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, Indiaen_US
dc.identifier.citationKhan Mohd. Fawad Farooq, Afzal Kamran, Arif S. H., Shahin Shadma. Prevalence of hepatitis B & C infections in prospective blood donors deferred due to history of jaundice. Indian Journal of Medical Research. 2022 Dec; 156(6): 750-755en_US
dc.identifier.issn0971-5916
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223703
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber6en_US
dc.relation.volume156en_US
dc.source.urihttps://doi.org/10.4103/ijmr.IJMR_2504_19en_US
dc.subjectBlood donorsen_US
dc.subjecthepatitis Ben_US
dc.subjecthepatitis Cen_US
dc.subjectjaundiceen_US
dc.subjectmedical history takingen_US
dc.subjectprevalenceen_US
dc.titlePrevalence of hepatitis B & C infections in prospective blood donors deferred due to history of jaundiceen_US
dc.typeJournal Articleen_US
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