Comparative Short term Efficacy and Tolerability of Methylphenidate and Atomoxetine in Attention Deficit Hyperactivity Disorder.
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Date
2014-07
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Abstract
Objective: To compare the short term efficacy and tolerability of
methylphenidate and atomoxetine in children with Attention deficit
hyperactivity disorder (ADHD).
Design: Open label randomized parallel group clinical trial.
Setting: Child Guidance Clinic of a tertiary care hospital of
Northern India from October 2010 to June 2012.
Participants: 69 patients (age 6-14 y) with a diagnosis of ADHD
receiving methylphenidate or atomoxetine.
Intervention: Methylphenidate (0.2-1 mg/kg/d) or atomoxetine
(0.5-1.2 mg/kg/d) for eight weeks.
Main outcome measures: Treatment response (>25% change in
baseline Vanderbilt ADHD Diagnostic Parent Rating Scale
(VADPRS); Vanderbilt ADHD Diagnostic Teacher Rating Scale
(VADTRS); Clinical Global Impression Severity Scale (CGI-S) at
eight weeks and adverse effects.
Results: Treatment response was observed in 90.7% patients
from methylphenidate group and 86.2% patients of atomoxetine
group at an average dose of 0.45 mg/kg/d and 0.61 mg/kg/d,
respectively. The patients showed comparable improvement on
VADPRS (P=0.500), VADTRS (P=0.264) and CGI-S (P=0.997).
Weight loss was significantly higher in methylphenidate group
(-0.57±0.78 kg; P=0.001), and heart rate increase was observed
at higher rate in atomoxetine group (7± 9 bpm; P=0.021).
Conclusion: Methylphenidate and atomoxetine are efficacious in
Indian children with ADHD at lesser doses than previously used.
Their efficacy and tolerability are comparable.
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Keywords
ADHD, Adverse events, Efficacy, Treatment dose
Citation
Garg Jasmin, Arun Priti, Chavan B S. Comparative Short term Efficacy and Tolerability of Methylphenidate and Atomoxetine in Attention Deficit Hyperactivity Disorder. Indian Pediatrics. 2014 July; 51(7): 550-554.