Pregnancy in women with epilepsy : preliminary results of Kerala registry of epilepsy and pregnancy.

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dc.contributor.authorThomas, S Ven_US
dc.contributor.authorIndrani, Len_US
dc.contributor.authorDevi, G Cen_US
dc.contributor.authorJacob, Sen_US
dc.contributor.authorBeegum, Jen_US
dc.contributor.authorJacob, P Pen_US
dc.contributor.authorKesavadas, Ken_US
dc.contributor.authorRadhakrishnan, Ken_US
dc.contributor.authorSarma, P Sen_US
dc.date.accessioned2001-03-17en_US
dc.date.accessioned2009-06-03T10:10:58Z
dc.date.available2001-03-17en_US
dc.date.available2009-06-03T10:10:58Z
dc.date.issued2001-03-17en_US
dc.description.abstractEighty-five women with epilepsy were followed up for reproductive functions under the registry of epilepsy and pregnancy. 32 of them had completed the pregnancy. Their mean age was 26 years and mean seizure frequency was 0.7 during current pregnancy. Nineteen of them (59.4%) had generalized epilepsy. Nine of them were not on any anti epileptic drugs (AED), 23 women were on various AEDs, 19 being on monotherapy. Only 40% of the women were taking folic acid during pregnancy. Pregnancy ended as spontaneous abortion in one patient. Nearly one third required cesarean section. Majority (87.5%) had term babies. Three (10.7%) babies had birth asphyxia. Six babies (21.4%) had low birth weight. Congenital malformations were detected in four cases (12.5%). Malformations included neural tube defects, talipes equinovarus and other minor anomalies. These babies were exposed to sodium valproate, carbamazepine or phenobarbitone. The risk of malformation was significantly greater (p<0.05) when the mother had generalized epilepsy. The odds ratio for risk of malformation was much higher with sodium valproate (6) than that with carbamazepine (1.2) or phenobarbitone (0.8). Majority of women with epilepsy had safe pregnancy and childbirth without any aggravation of epilepsy.en_US
dc.description.affiliationDepartment of Neurology, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum - 695011, India.en_US
dc.identifier.citationThomas SV, Indrani L, Devi GC, Jacob S, Beegum J, Jacob PP, Kesavadas K, Radhakrishnan K, Sarma PS. Pregnancy in women with epilepsy : preliminary results of Kerala registry of epilepsy and pregnancy. Neurology India. 2001 Mar; 49(1): 60-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/120053
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAnticonvulsants --adverse effectsen_US
dc.subject.meshEpilepsy --drug therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Newborn, Diseases --epidemiologyen_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications --drug therapyen_US
dc.subject.meshRegistries --statistics & numerical dataen_US
dc.titlePregnancy in women with epilepsy : preliminary results of Kerala registry of epilepsy and pregnancy.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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