Antioxidant activity, total phenolic and flavonoid contents of selected medicinal plants used for liver diseases and its classification with chemometrics

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dc.contributor.authorWidodo, Hartoen_US
dc.contributor.authorSismindari, Sismindarien_US
dc.contributor.authorWidya, Asmaraen_US
dc.contributor.authorAbdul, Rohmanen_US
dc.date.accessioned2020-10-16T08:55:37Z
dc.date.available2020-10-16T08:55:37Z
dc.date.issued2019-06
dc.description.abstractLiver disease has become one of the major health problems in the world, and the death rate is going rapidly toincrease. Oxidative stress plays a crucial role in the emerging, development, and the progression of liver diseases.Ethnobotanical research has an undoubted profound impact on the development of numerous new drugs. The aimof this research, therefore, was to examine the antioxidant activities of 14 selected plants used for treating liverdiseases by traditional healers of Indonesia ethnicities and to classify these plants using chemometrics of principalcomponent analysis (PCA). The extraction using methanol as the solvent was performed with two stages maceration.Total phenolic and flavonoid compounds were determined by Folin–Ciocalteau and AlCl3 method, respectively,whereas antioxidant activity was estimated using 2,2′-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging,trolox equivalent antioxidant capacity (TEAC), and ferric reducing antioxidant power (FRAP) assay. Among 19methanol extracts of 14 plants, the leaves of Baccaurea racemosa, Macaranga subpeltata, and Piper sp. showed thehighest antioxidant properties. The phenolic content correlated with TEAC, FRAP, and DPPH radical scavengingactivity, while flavonoid did not significantly affect these antioxidant activity methods. PCA successfully classifiedthe plant samples using the variables of antioxidant activities and phenolic-flavonoid contents. The selected plantshave promising antioxidant properties which support their utilization for either liver diseases medication or oxidativestress-related diseases preventionen_US
dc.identifier.affiliationsCentre Study of Biotechnology, Gadjah Mada University, Yogyakarta, Indonesiaen_US
dc.identifier.affiliationsMedicinal Plant and Traditional Medicine Research and Development Centre (MPTMRDC)—NiHRD RI, Indonesia.en_US
dc.identifier.affiliationsFaculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia.en_US
dc.identifier.affiliationsDepartment of Microbiology, Faculty of Veterinary Medicine, Gadjah Mada University, Yogyakarta, Indonesia.en_US
dc.identifier.affiliationsFaculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia.en_US
dc.identifier.affiliationsInstitute of Halal Industry and Systems, Gadjah Mada University, Yogyakarta, Indonesia.en_US
dc.identifier.citationWidodo Harto, Sismindari Sismindari, Widya Asmara, Abdul Rohman. Antioxidant activity, total phenolic and flavonoid contents of selected medicinal plants used for liver diseases and its classification with chemometrics. Journal of Applied Pharmaceutical Science. 2019 Jun; 2019 Jun: 099-105en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210393
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2019.90614en_US
dc.subjectAntioxidant activityen_US
dc.subjectflavonoiden_US
dc.subjectphenolicen_US
dc.subjectmedicinal planten_US
dc.subjecttraditional healeren_US
dc.subjectprincipal component analysisen_US
dc.titleAntioxidant activity, total phenolic and flavonoid contents of selected medicinal plants used for liver diseases and its classification with chemometricsen_US
dc.typeJournal Articleen_US
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