Radioactive iodine therapy in Graves' hyperthyroidism: a prospective study from a tertiary referral centre in north India.

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dc.contributor.authorSankar, Ren_US
dc.contributor.authorSekhri, Ten_US
dc.contributor.authorSripathy, Gen_US
dc.contributor.authorWalia, R Pen_US
dc.contributor.authorJain, S Ken_US
dc.date.accessioned2005-07-30en_US
dc.date.accessioned2009-05-31T03:53:46Z
dc.date.available2005-07-30en_US
dc.date.available2009-05-31T03:53:46Z
dc.date.issued2005-07-30en_US
dc.description.abstractBACKGROUND: Radioactive iodine has gained widespread acceptance as the first-line therapy for Graves' hyperthyroidism and is the preferred treatment option in most situations. OBJECTIVE: A prospective study was conducted to look at the therapeutic practice of use of radioactive iodine in the treatment of Graves' hyperthyroidism, to determine whether the expected or desired therapeutic outcome is achieved. SETTINGS: A tertiary referral centre in north India, Delhi that caters to patients with thyroid disorders. METHODS: One hundred and seventy four consecutive subjects with Graves' hyperthyroidism, who were given radioactive iodine were followed up. RESULTS: There were 59 (33.9%) males and 115 (66.1%) females. The mean age was 41.8 +/- 9 years. The dose of radioactive iodine ranged from 2 mCi to 15 mCi and the mean dose administered was 5.2 +/- 1.9 mCi. After one year following radioactive iodine therapy, 29 (16.7%) subjects were euthyroid, 51 (29.3%) were hypothyroid and the remaining 94 (54%) had persisting hyperthyroidism. Those subjects with persisting hyperthyroidism at one year after radioactive iodine had received a significantly lower dose compared to the groups who had achieved cure (either euthyroidism or hypothyroidism). CONCLUSION: The study shows that the current practice of empirical low dose radioactive iodine therapy to avoid hypothyroidism results in majority of patients having persisting hyperthyroidism. There is a need to take a new look at the current practice to increase the cure rate.en_US
dc.description.affiliationThyroid Research Centre, Institute of Nuclear Medicine and Allied Sciences, Defence Research and Development Organization, Lucknow Road, Timarpur, Delhi - 110054.en_US
dc.identifier.citationSankar R, Sekhri T, Sripathy G, Walia RP, Jain SK. Radioactive iodine therapy in Graves' hyperthyroidism: a prospective study from a tertiary referral centre in north India. Journal of the Association of Physicians of India. 2005 Jul; 53(): 603-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/94292
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshDose-Response Relationship, Radiationen_US
dc.subject.meshFemaleen_US
dc.subject.meshGoiter, Nodular --drug therapyen_US
dc.subject.meshGraves Disease --radiotherapyen_US
dc.subject.meshHospitalsen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperthyroidism --pathologyen_US
dc.subject.meshIndiaen_US
dc.subject.meshIodine Radioisotopes --administration & dosageen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRadioimmunoassayen_US
dc.subject.meshRadiotherapy Dosageen_US
dc.subject.meshThyroid Gland --drug effectsen_US
dc.subject.meshThyroid Hormones --blooden_US
dc.subject.meshThyrotropin --blooden_US
dc.subject.meshTreatment Outcomeen_US
dc.titleRadioactive iodine therapy in Graves' hyperthyroidism: a prospective study from a tertiary referral centre in north India.en_US
dc.typeJournal Articleen_US
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