Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats.

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dc.contributor.authorPavana, Pen_US
dc.contributor.authorManoharan, Sen_US
dc.contributor.authorRenju, G Len_US
dc.contributor.authorSethupathy, Sen_US
dc.date.accessioned2007-10-15en_US
dc.date.accessioned2009-06-02T03:36:18Z
dc.date.available2007-10-15en_US
dc.date.available2009-06-02T03:36:18Z
dc.date.issued2007-10-15en_US
dc.description.abstractDiabetes mellitus is a worldwide leading metabolic syndrome, associated with profound alterations in carbohydrate, lipids, lipoproteins and protein metabolisms. Worldwide, traditional practitioners for the treatment of diabetes and its complications use a wide variety of medicinal plants. In the present study the aqueous extract of Tephrosia purpurea leaves (TpALet) was evaluated for its antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats. Profound alterations in the concentrations of blood glucose, lipids and lipoproteins were observed in diabetic rats. Oral administration of TpALet to diabetic rats at a dose of 600 mg/kg body weight significantly reduced the level of blood glucose and increased the level of plasma insulin as well as normalized the lipids and lipoproteins profile. The present study thus demonstrated that TpALet has prominent antihyperglycemic and antihyperlipidemic effects in streptozotocin induced diabetic rats.en_US
dc.description.affiliationDepartment of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, India.en_US
dc.identifier.citationPavana P, Manoharan S, Renju GL, Sethupathy S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. Journal of Environmental Biology. 2007 Oct; 28(4): 833-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/113181
dc.language.isoengen_US
dc.source.urihttps://www.geocities.com/j_environ_biol/en_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntilipemic Agents --therapeutic useen_US
dc.subject.meshBlood Glucose --analysisen_US
dc.subject.meshDiabetes Mellitus, Experimental --drug therapyen_US
dc.subject.meshHypoglycemic Agents --therapeutic useen_US
dc.subject.meshInsulin --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshPlant Leaves --chemistryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshStreptozocinen_US
dc.subject.meshTephrosia --chemistryen_US
dc.titleAntihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats.en_US
dc.typeJournal Articleen_US
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