The sustained virologic response of nonresponder hepatitis C virus patients with retreatment.

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dc.contributor.authorAkhan, Sila Cetin
dc.contributor.authorGurel, Erdem
dc.contributor.authorSayan, Murat
dc.date.accessioned2012-10-04T06:28:29Z
dc.date.available2012-10-04T06:28:29Z
dc.date.issued2011-01
dc.description.abstractIn contrast to the large number of studies in treatment-naive patients, the effectiveness of retreatment in patients who have previously failed pegylated interferon based therapy is not much reported. Objectives: The aim of this retrospective study was to focus on the efficacy of pegylated interferon alpha and ribavirin in retreated chronic hepatitis C patients. Patients and Methods: All patients were treated with pegylated interferon alpha either 2a (180 μg) or 2b (1.5μg/kg) subcutaneously once weekly for a 48-week period, plus ribavirin 1000-1200 mg/day. The patient who had a negative HCV RNA at the end of 48 weeks were followed up for 24 weeks, and the patients who relapsed in the post-treatment follow-up period of 24 weeks were treated again with pegylated interferon alpha; but if the first treatment was administered with pegylated interferon alpha 2a, the second was administered with pegylated interferon alpha 2b and if pegylated interferon alpha 2b, then the second with pegylated interferon alpha 2a. Results: We evaluated the outcome of our patients with chronic HCV who achieved a viral response at the end of the therapy, but did not achive sustained virologic response; 54% (38/70) of patients did achieve sustained virologic response, while 46% (32/70) of patients did not (eight patients did not achieve early virologic response, five patients were nonresponders at 24th week of the treatment, the remaining 19 patient had negative HCV at the end of the therapy but did not achieve sustained virologic response). We began from 19 patients to 8 patients, who had negative HCV RNA at the end of the treatment, but did not achieve sustained virologic response, interferon plus ribavirin therapy again. If the patient had interferon alpha 2a, we gave in the second tour alpha 2b; and if alpha 2b, then alpha 2a. The early virologic response of these nine patients were found to be 63% (5/8). These 5 patients who had rapid virologic response and early virologic response at the second therapy achieved sustained virologic response this time. Conclusions: These findings suggest that the standard 48-week treatment is insufficient and that an extended course of treatment may be necessary. Relapse is a poorly understood clinical outcome in the treatment of chronic HCV patients. Retreament can give a chance to some patients specially who have early virologic response and negative HCV RNA at the end of the first therapy.en_US
dc.identifier.citationAkhan Sila Cetin, Gurel Erdem, Sayan Murat. The sustained virologic response of nonresponder hepatitis C virus patients with retreatment. Indian Journal of Pathology & Microbiology. 2011 Jan-Mar 54(1): 81-84.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/141921
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2011;volume=54;issue=1;spage=81;epage=84;aulast=Akhanen_US
dc.subjectHepatitis C virusen_US
dc.subjectpegylated interferonen_US
dc.subjectretreatmenten_US
dc.subject.meshAntiviral Agents --administration & dosage
dc.subject.meshFemale
dc.subject.meshHepacivirus --isolation & purification
dc.subject.meshHepatitis C, Chronic --drug therapy
dc.subject.meshHumans
dc.subject.meshInjections, Subcutaneous
dc.subject.meshInterferon-alpha --administration & dosage
dc.subject.meshMale
dc.subject.meshPolyethylene Glycols --administration & dosage
dc.subject.meshRecombinant Proteins
dc.subject.meshRecurrence
dc.subject.meshRetreatment --methods
dc.subject.meshRetrospective Studies
dc.subject.meshRibavirin --administration & dosage
dc.subject.meshTreatment Outcome
dc.subject.meshViral Load
dc.titleThe sustained virologic response of nonresponder hepatitis C virus patients with retreatment.en_US
dc.typeArticleen_US
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