Therapeutic efficacy of artesunate in Plasmodium vivax malaria in Thailand.

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dc.contributor.authorHamedi, Yen_US
dc.contributor.authorSafa, Omiden_US
dc.contributor.authorZare, Sen_US
dc.contributor.authorTan-ariya, Pen_US
dc.contributor.authorKojima, Sen_US
dc.contributor.authorLooareesuwan, Sen_US
dc.date.accessioned2009-05-27T14:39:53Z
dc.date.available2009-05-27T14:39:53Z
dc.date.issued2004-09-04en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractOur previous study showed that in vitro susceptibility of Plasmodium vivax to chloroquine has significantly decreased in Thailand within the past two decades. Thus, the evaluation of alternative antimalarials for treatment of vivax malaria is needed. The aim of this study was to examine parasitological and clinical efficacy of an artemisinin derivative (artesunate) for the treatment of vivax malaria in patients who were admitted to the Bangkok Hospital for Tropical Diseases. We randomly allocated patients aged 12-56 years to receive 3.3mg/kg (adult dose 200 mg) on the first day, and for the next four days each patient was given 1.65 mg/kg orally (adult dose 100 mg), total dose = 600 mg. After the five-day course of artesunate, primaquine was given: a single oral dose of 15mg for 14 days. A total number of 42 patients received treatment. All participants were followed up for 28 days. In all the cases, both parasitemia and fever were resolved rapidly; the mean fever clearance time and parasite clearance time, 14.6 and 36.7 hours, respectively, showed that therapeutic response to artesunate was better than that of chloroquine. The 14-day cure rate was 100%, but reappearance of parasitemia was seen in two patients on days 21 and 25 following treatment, respectively. These two cases of failure rate should be considered as true relapse rather than recrudescence, since the relapse interval in Southeast Asian vivax malaria according to recent findings seems to be 3 weeks after start of treatment, if primaquine is not given or an inadequate amount is given. In conclusion, artesunate might be useful in treatment of vivax malaria, causing a good blood schizontocidal effect. However, to prevent emerging resistance it should never be used alone.en_US
dc.description.affiliationDepartment of Parasitology, Bandar Abbas School of Medicine, Hormozgan University of Medical Sciences, Iran. yhamedi@yahoo.comen_US
dc.identifier.citationHamedi Y, Safa O, Zare S, Tan-ariya P, Kojima S, Looareesuwan S. Therapeutic efficacy of artesunate in Plasmodium vivax malaria in Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Sep; 35(3): 570-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/30745
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_3/13-3248.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntimalarials --administration & dosageen_US
dc.subject.meshArtemisinins --administration & dosageen_US
dc.subject.meshChilden_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshDrug Therapy, Combinationen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Vivax --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPlasmodium vivax --drug effectsen_US
dc.subject.meshPrimaquine --therapeutic useen_US
dc.subject.meshSesquiterpenes --administration & dosageen_US
dc.subject.meshThailanden_US
dc.subject.meshTreatment Outcomeen_US
dc.titleTherapeutic efficacy of artesunate in Plasmodium vivax malaria in Thailand.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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