Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study.

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dc.contributor.authorJittiwutikan, Jen_US
dc.contributor.authorSrisurapanont, Men_US
dc.contributor.authorJarusuraisin, Nen_US
dc.date.accessioned2009-05-27T18:55:57Z
dc.date.available2009-05-27T18:55:57Z
dc.date.issued1997-09-05en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractTemporary inability to function without amphetamine and the experience of withdrawal syndrome enhance the tendency for repetitive use. The investigators proposed to examine the therapeutic effects of amineptine, an antidepressant with dopamine reuptake inhibition effect, for the treatment of amphetamine withdrawal. The 14-day study was carried out on a randomised, double-blind, placebo-controlled design. The authors assessed the severity of amphetamine withdrawal syndrome by using two measures and performed both end-point and intent-to-treat analyses. The results showed that amineptine helped relieve a depressed mood within one week and improved the general condition within 2 weeks. In conclusion, amineptine is effective in rapid relief of depressed mood and improves the general condition of patients with amphetamine withdrawal. Since the amphetamine withdrawal may last for several weeks, studies with longer duration should be conducted before incorporating amineptine into the clinical practice a of amphetamine withdrawal treatment.en_US
dc.description.affiliationNorthern Drug Dependence Treatment Centre, Chiang Mai, Thailand.en_US
dc.identifier.citationJittiwutikan J, Srisurapanont M, Jarusuraisin N. Amineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study. Journal of the Medical Association of Thailand. 1997 Sep; 80(9): 587-92en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40138
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAmphetamine-Related Disorders --drug therapyen_US
dc.subject.meshAntidepressive Agents, Second-Generation --therapeutic useen_US
dc.subject.meshDepression --drug therapyen_US
dc.subject.meshDibenzocycloheptenes --therapeutic useen_US
dc.subject.meshDopamine Uptake Inhibitors --therapeutic useen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSubstance Withdrawal Syndrome --drug therapyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAmineptine in the treatment of amphetamine withdrawal: a placebo-controlled, randomised, double-blind study.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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