A Cross-sectional Study on Assessment of Estimated Glomerular Filtration Rate in Patients with Stable Chronic Obstructive Pulmonary Disease

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dc.contributor.authorMondal, Sen_US
dc.contributor.authorChoudhury, Sen_US
dc.contributor.authorSaha, Ken_US
dc.contributor.authorDey, SKen_US
dc.contributor.authorDas, SKen_US
dc.date.accessioned2024-12-07T11:59:02Z
dc.date.available2024-12-07T11:59:02Z
dc.date.issued2024-03
dc.description.abstractBackground: Chronic obstructive pulmonary disease (COPD) is a systemic disease with several extrapulmonary comorbidities. However, studies to find out the relationship between COPD and renal impairment are scarce. This study aimed to assess the relationship of estimated glomerular filtration rate (eGFR) with chronic obstructive pulmonary disease assessment test (CAT) score, modified medical research council (mMRC) scale, 6-minute walking test (6MWT), and postbronchodilator forced expiratory volume (FEV1) in COPD and to compare the reduction of eGFR in different GOLD stages. Materials and methods: A total of 240 stable COPD patients attending the outpatient department (OPD) were randomly selected between November 2019 and October 2020. Participants had spirometry, Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging, CAT score, mMRC grading, and 6MWT. Serum creatinine was obtained and eGFR was calculated. The interpretation was made by comparing the results of the eGFR and GOLD stages with different parameters. Results: In patients with normal eGFR, the mean mMRC score was 2.00 ± 0.86, 6MWD was 324.98 ± 47.08 m, and CAT score was 14.23± 6.09. With reduced eGFR, the mean mMRC score was 2.32 ± 1.17, 6MWD was 278.30 ± 75.98 m, and CAT scoring was 19.38 ± 9.05. These were statistically significant (p = 0.0145, p < 0.0001, and p < 0.0001, respectively). A negative correlation was found between eGFR vs GOLD stages; the Pearson correlation coefficient (r) was ?0.014. Conclusion: Reduction of eGFR was seen in stable COPD patients with higher GOLD stages. Patients with reduced eGFR had higher mMRC grade, increased CAT score, and reduced 6MWD. So, routine estimation of eGFR in patients of stable COPD is advocated to assess renal involvement.en_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Medical College Kolkata, Kolkata, West Bengal, Indiaen_US
dc.identifier.affiliationsDepartment of Respiratory Medicine, Dey’s Research Centre, Howrah, West Bengal, Indiaen_US
dc.identifier.citationMondal S, Choudhury S, Saha K, Dey SK, Das SK. A Cross-sectional Study on Assessment of Estimated Glomerular Filtration Rate in Patients with Stable Chronic Obstructive Pulmonary Disease. The Indian Journal of Chest Diseases and Allied Sciences. 2024 Mar; 66(1): 7-10en_US
dc.identifier.issn0377-9343
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/242304
dc.languageenen_US
dc.publisherJaypee Brothers Medical Publishers Pvt. Ltd.en_US
dc.relation.issuenumber1en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.5005/jp-journals-11007-0104en_US
dc.subjectChronic obstructive pulmonary diseaseen_US
dc.subjectEstimated glomerular filtration rateen_US
dc.subjectGlobal Initiative for chronic obstructive lung disease stageen_US
dc.subjectRenal involvement.en_US
dc.titleA Cross-sectional Study on Assessment of Estimated Glomerular Filtration Rate in Patients with Stable Chronic Obstructive Pulmonary Diseaseen_US
dc.typeJournal Articleen_US
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