Morphological characteristics of leukemia cells in acute myeloblastic leukemia with t(8;21)(q22;q22): possible predictability of t(8;21).

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dc.contributor.authorPurwanto, Ibnu
dc.contributor.authorTatsumi, Eiji
dc.contributor.authorSyampurnawati, Meilani
dc.contributor.authorFuruta, Kaho
dc.contributor.authorHayashi, Yoshitaka
dc.contributor.authorSaigo, Katsuyasu
dc.contributor.authorMasuda, Kayoko
dc.contributor.authorSakoda, Hiroyuki
dc.contributor.authorKawano, Seiji
dc.contributor.authorKumagai, Shunichi
dc.contributor.authorNagai, Ken-Ichi
dc.contributor.authorTakahashi, Takayuki
dc.contributor.authorIsono, Setsuki
dc.contributor.authorKondo, Shin-Ichi
dc.contributor.authorKurnianda, Johan
dc.contributor.authorHaryana, Sofia Mubarika
dc.date.accessioned2013-10-30T08:33:44Z
dc.date.available2013-10-30T08:33:44Z
dc.date.issued2007-04
dc.description.abstractThe laboratory systems for chromosomal analysis or the detection of fusion genes are generally not available in Indonesia. Therefore, bone marrow (BM) morphological analysis should be developed and applied to get an accurate diagnosis. In this study the BM smears of eight (8) cases of acute myeloblastic leukemia (AML) which had already been known to have t(8;21)(q22;q22), were morphologically evaluated in order to find out the characteristics, which might be used to predict t(8;21)(q22;q22) or the presence of AML1-ETO(MTG8) fusion gene. All of the cases belonged to AML-M2. The morphological characteristics, indicative of t(8;21) were pink colored cytoplasm in mature neutrophil (75%), neutrophilic myelocytes or metamyelocytes without granules or with scarce granules (2.3%), eosinophilia (eosinophilic myelocytes and metamyelocytes) (above 5%), myelocytes with abundant granules 8.5%, and low percentage of type I blasts (below 10%). These characteristics were not observed in AML-M2 cases without t(8;21) or AML1-ETO(MTG8). The myelocytes with abundant granules have not been described so far, while other characteristics were in line with the findings of Nakamura et al (Leukemia 1997;11:651-55).en_US
dc.identifier.citationPurwanto Ibnu, Tatsumi Eiji, Syampurnawati Meilani, Furuta Kaho, Hayashi Yoshitaka, Saigo Katsuyasu, Masuda Kayoko, Sakoda Hiroyuki, Kawano Seiji, Kumagai Shunichi, Nagai Ken-Ichi, Takahashi Takayuki, Isono Setsuki, Kondo Shin-Ichi, Kurnianda Johan, Haryana Sofia Mubarika. Morphological characteristics of leukemia cells in acute myeloblastic leukemia with t(8;21)(q22;q22): possible predictability of t(8;21). Medical Journal of Indonesia. 2007 Apr; 16(2): 84-89.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149086
dc.language.isoenen_US
dc.source.urihttps://mji.ui.ac.id/journal/index.php/mji/article/view/260en_US
dc.subjectPML-RARA fusion geneen_US
dc.subjectAML1-ETO (MTG8)en_US
dc.subjectmyelocytesen_US
dc.subjectabundant granulen_US
dc.subject.meshLeukemia, Myeloid, Acuteen_US
dc.subject.meshGranulocyte Precursor Cellsen_US
dc.titleMorphological characteristics of leukemia cells in acute myeloblastic leukemia with t(8;21)(q22;q22): possible predictability of t(8;21).en_US
dc.typeArticleen_US
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