Cluster-analysis & patterns of dissemination of multidrug resistance among clinical strains of Vibrio cholerae in Calcutta, India.

Simple item page
dc.contributor.authorRamamurthy, Ten_US
dc.contributor.authorRajendran, Ken_US
dc.contributor.authorGarg, Pen_US
dc.contributor.authorShimada, Ten_US
dc.contributor.authorBasu, Aen_US
dc.contributor.authorChowdhury, N Ren_US
dc.contributor.authorNandy, R Ken_US
dc.contributor.authorYamasaki, Sen_US
dc.contributor.authorBhattacharya, S Ken_US
dc.contributor.authorTakeda, Yen_US
dc.contributor.authorNair, G Ben_US
dc.date.accessioned2000-09-30en_US
dc.date.accessioned2009-05-27T08:22:31Z
dc.date.available2000-09-30en_US
dc.date.available2009-05-27T08:22:31Z
dc.date.issued2000-09-30en_US
dc.description.abstractBACKGROUND & OBJECTIVES: Antimicrobial resistance among Vibrio cholerae has been monitored for several years in Calcutta. To investigate the changing trends in multidrug resistance (MDR) among different serogroups of V. cholerae and to perform software assisted cluster analysis the current study was undertaken. METHODS: Strains isolated from patients with cholera and "cholera-like" diarrhoea admitted in the Infectious Diseases Hospital, Calcutta were analysed. Eight hundred and forty V. cholerae strains isolated from 1992 through 1997 were tested for susceptibility to 11 antibiotics. Cluster analysis was done using SPSS software. RESULTS: Most of the strains exhibited MDR with fluctuating trends as the resistance profile diverged each year. A total of 119 different resistance profiles exhibited by V. cholerae O1, O139 and non-O1, non-O139 serogroups were analysed by cluster combination method. During 1993 and 1994, 53 per cent of V. cholerae O139 and 82 per cent of V. cholerae O1 serogroups, respectively, exhibited maximal number of new resistance patterns. The frequency of new resistance patterns among V. cholerae non-O1, non-O139 was constantly high (33-47%) during 1995 to 1997. INTERPRETATION & CONCLUSIONS: With a few exceptions, preponderance of the resistance profiles was generally not confined to any serogroup. The cluster analysis depicted dissemination of some of the resistance patterns commonly found among V. cholerae non-O1, non-O139 belonging to different serogroups to the O139 serogroup in the succeeding years. In this study we have shown that the V. cholerae strains are resistant to several antibiotics with constant change in the MDR profiles. It is imperative to define the susceptibility pattern of the strains to determine the effective drug of choice for the treatment of cholera.en_US
dc.description.affiliationNational Institute of Cholera & Enteric Diseases (ICMR), Calcutta.en_US
dc.identifier.citationRamamurthy T, Rajendran K, Garg P, Shimada T, Basu A, Chowdhury NR, Nandy RK, Yamasaki S, Bhattacharya SK, Takeda Y, Nair GB. Cluster-analysis & patterns of dissemination of multidrug resistance among clinical strains of Vibrio cholerae in Calcutta, India. Indian Journal of Medical Research. 2000 Sep; 112(): 78-85en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/24226
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshCluster Analysisen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshDrug Resistance, Multipleen_US
dc.subject.meshVibrio cholerae --classificationen_US
dc.titleCluster-analysis & patterns of dissemination of multidrug resistance among clinical strains of Vibrio cholerae in Calcutta, India.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research