In vitro Evaluation of Antibacterial Activity of Various Crude Leaf Extracts of Indian Sacred Plant, Ocimum sanctum L.
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Date
2011-07
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Abstract
The medical world is on an immense requirement to discover novel antibiotics due to
widespread emergence of resistance among microbial pathogens against currently available
antibiotics. Traditional plants have been proved to be better source in the search for novel
antimicrobial compounds. In such effort, we accessed the susceptibilities of some clinically
significant bacterial species against various extracts made up from leaves of Ocimum
sanctum L. (family: Lamiaceae). Antibacterial activity of crude extracts was found to be
reliant on the nature of extract and the bacterial strains evaluated. Methanol extract was
found to have comparatively higher activity than other organic and aqueous extracts. Grampositive
bacteria showed variable susceptibilities while Gram-negative Salmonella typhi has
shown to be completely resistance to all the tested extracts. Minimum inhibitory
concentration data showed hopeful results as some of the extracts exhibited significant
inhibitions of bacteria even at low concentrations. This study indicated that leaves of
Ocimum sanctum L. have significant antibacterial activity and it could be very useful in the
discovery of novel antibacterial/antimicrobial agents.
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Keywords
Ocimum sanctum, Indian sacred plant, resistance, antibiotics, natural products, antibacterial potential, susceptibility assay, minimum inhibitory concentration
Citation
Goyal Pankaj, Kaushik Purshotam. In vitro Evaluation of Antibacterial Activity of Various Crude Leaf Extracts of Indian Sacred Plant, Ocimum sanctum L. British Microbiology Research Journal. 2011 July; 1(3): 70-78.