Metaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosis

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dc.contributor.authorLalhruaizela, Samuelen_US
dc.contributor.authorMehra, Bhupendraen_US
dc.date.accessioned2020-11-18T10:04:11Z
dc.date.available2020-11-18T10:04:11Z
dc.date.issued2020-04
dc.description.abstractMetaplastic breast carcinoma (MBC) has an incidence of <1% of all breast cancers and MBC with chondrosarcomatous differentiation is even more rare, <0.1% of all cases. The World Health Organization have classified MBC into pure epithelial-type and mixed epithelial and mesenchymal type. The epithelial-type MBC is sub-classified into squamous cell carcinoma, adenosquamous carcinoma and adenocarcinoma with spindle cell differentiation; mixed type MBC is sub-classified into carcinosarcoma and carcinoma with osseous and chondroid metaplasia. Metaplastic carcinomas of the breast are characterized by large tumour size and rapid  growth, and they are usually estrogen receptor, progesterone receptor, and HER2/neu negative and tend to have a worse prognosis than other triple negative breast cancers. There is a noteworthy increased risk of tumour recurrence and a worse prognosis with MBC compared with invasive lobular carcinoma and infiltrating duct carcinoma. We report a case of metaplastic carcinoma with extensive chondroid differentiation that is chondrosarcoma and chondroid metaplasia along with classic infiltrating duct carcinoma with involvement of ipsilateral axillary lymph nodes.en_US
dc.identifier.affiliationsAssistant Professor, Department of Surgery, Zoram Medical College, Mizoram, Indiaen_US
dc.identifier.affiliationsProfessor, Department of Surgery, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, Indiaen_US
dc.identifier.citationLalhruaizela Samuel, Mehra Bhupendra. Metaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosis. International Surgery Journal. 2020 Apr; 7(4): 1277-1279en_US
dc.identifier.issn2349-3305
dc.identifier.issn2349-2902
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/212823
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber4en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-2902.isj20201000en_US
dc.subjectChondrosarcomaen_US
dc.subjectCarcinosarcomaen_US
dc.subjectMetaplasticen_US
dc.subjectMesenchymalen_US
dc.titleMetaplastic breast carcinoma with chondrosarcomatous differentiation: an unusual disease with a worse prognosisen_US
dc.typeJournal Articleen_US
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