Changes in anti-oxidant enzymes and lipid peroxidation in hyaline membrane disease.

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dc.contributor.authorSingh, S Ken_US
dc.contributor.authorTandon, Aen_US
dc.contributor.authorKumari, Sen_US
dc.contributor.authorRavi, R Nen_US
dc.contributor.authorRay, G Nen_US
dc.contributor.authorBatra, Sen_US
dc.date.accessioned1998-07-25en_US
dc.date.accessioned2009-05-30T14:47:32Z
dc.date.available1998-07-25en_US
dc.date.available2009-05-30T14:47:32Z
dc.date.issued1998-07-25en_US
dc.description.abstractThis study was conducted to elucidate the changes in key antioxidant enzymes e.g. Superoxide dismutase (SOD), Catalase and Glutathione peroxidase (GPx) along with lipid peroxidation (LPO) in preterm newborns having hyaline membrane disease (HMD) and thus to find out role of free radicals mediated injury in this disease. Twenty one preterm appropriate for gestational age newborns were included in the study. Eleven of them had hyaline membrane disease and ten were controls without any disease. Status of superoxide dismutase, glutathione peroxidase and catalase, the three main antioxidant enzymes and lipid peroxidation was monitored at 12-24 hours of age. SOD and catalase were found significantly elevated in cases having hyaline membrane disease along with significantly more lipid peroxidation. It is evident that free radicals result in the induction of the antioxidant enzymes; however, the elevated enzymes are unable to counteract the high concentration of the free radicals which are being produced in the diseased cases and leads to increase in lipid peroxidation in hyaline membrane disease. It is concluded that free radicals play a significant role in hyaline membrane disease and the preterm newborns have ability to induce antioxidant enzymes in response to oxidative stress.en_US
dc.description.affiliationDepartment of Pediatrics and Biochemistry, Lady Hardinge Medical College and Associated, Kalawati Saran Children's Hospital, New Delhi.en_US
dc.identifier.citationSingh SK, Tandon A, Kumari S, Ravi RN, Ray GN, Batra S. Changes in anti-oxidant enzymes and lipid peroxidation in hyaline membrane disease. Indian Journal of Pediatrics. 1998 Jul-Aug; 65(4): 609-14en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/82995
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshCatalase --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshFree Radicals --metabolismen_US
dc.subject.meshGlutathione Peroxidase --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshHyaline Membrane Disease --diagnosisen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLipid Peroxidation --physiologyen_US
dc.subject.meshLung --physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshSuperoxide Dismutase --blooden_US
dc.titleChanges in anti-oxidant enzymes and lipid peroxidation in hyaline membrane disease.en_US
dc.typeJournal Articleen_US
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