Serum Zinc Level in Persons with Prediabetes and it’s Relation with Glycemic Status Attending Tertiary Care Hospital in Bangladesh

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dc.contributor.authorMostafa, Hasan Rajiben_US
dc.contributor.authorFariduddin, Md.en_US
dc.contributor.authorSelim, Shahjadaen_US
dc.contributor.authorHasanat, M Aen_US
dc.contributor.authorIslam, Moinulen_US
dc.contributor.authorHoque, Fazlulen_US
dc.contributor.authorMustari, Marufaen_US
dc.contributor.authorMahjabeen, Samiraen_US
dc.date.accessioned2020-09-24T07:26:49Z
dc.date.available2020-09-24T07:26:49Z
dc.date.issued2020-03
dc.description.abstractBackground: Type 2 diabetes mellitus is becoming one of themajor health problems worldwide. Especially in South EastAsia, type 2 diabetes has gained critical significance. Asprediabetes prevalence is increasing worldwide, it has becomean important concern to prevent diabetes at an early stage inBangladesh.Objectives: Estimation of serum zinc level and establishmentof its relation with glycemic status in individuals with prediabetes.Materials and Methods: This cross-sectional studyencompassed 126 (age: 35.09±9.96 years, mean ± SD; Sex:16/110, M/F) subjects with prediabetes and 126(age:29.08±9.28 years, mean ± SD; Sex: 22/104, M/F) healthynondiabetic controls from the out-patient department ofEndocrinology, BSMMU consecutively. Serum zinc wasmeasured by using Atomic Absorption Spectrophotometry.Height, weight, waist circumference, acanthosis nigricans,hypertension, SGPT& serum creatinine were recorded asconfounding variables.Results: Serum zinc level in persons with prediabetes waslower than that in control (0.76±0.01 vs. 0.78±0.01mg/L,M±SEM, p=0.28). There was statistically significant differencefor zinc level in gender groups (M vs. F: 0.84±0.02 vs.0.75±0.01 mg/L, M±SEM, p<0.001) and monthly family incomegroups (p=0.02). Also zinc level was statistically similar amongglycemic status groups apart from zinc level in between controland combined glucose intolerance (CGI) groups (control vs.CGT: 0.78±0.01 vs. 0.72±0.02mg/L, M±SEM, p=0.03). Amongcases comparisons between groups with or without risk factorslike: smoking (0.72±0.03 vs. 0.76±0.10 mg/L, p=0.42),smokeless tobacco (0.73±0.03 vs. 0.76±0.01mg/L, p=0.46),hypertension (0.80±0.03 vs. 0.75±0.01 mg/L, p= 0.14), familyhistory of DM (0.75±0.02 vs. 0.77±0.02mg/L, p=0.52), familyhistory of CVD (0.74±0.02vs.0.77±0.01mg/L,p=0.28), overweight (0.76±0.01 vs.0.74±0.05mg/L, P=0.59), waistcircumference (0.75±0.01 vs. 0.79±0.04mg/L, p=0.40) andacanthosis nigricans (0.75±0.02 vs. 0.76±0.02mg/L, p=0.70),showed no statistically significant difference. None of thevariables like age (r= -0.02, p=0.19), BMI (r= 0.14, p=0.12),FPG (r= -0.05, p=0.60) and PG 2h after 75g glucose (r=0.10,p=0.28), HbA1c (r=0.04, p=0.64), serum creatinine (r=0.01,p=0.87) showed significant relationship with the level of zincexcept SGPT which showed significant relation with zincamong cases (r= 0.28, p=0.002) and among all participants(r=0.17, p=0.008) but not in control group (r=0.07, p=0.43).Conclusion: It is concluded that persons with prediabetes hadserum zinc level within normal limit and there was found nostatistically significant relationship between HbA1c and zincen_US
dc.identifier.affiliationsMedical Officer, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, Bangladeshen_US
dc.identifier.affiliationsChairman &Professor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, Bangladesh.en_US
dc.identifier.affiliationsAssociate Professor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, Bangladeshen_US
dc.identifier.affiliationsProfessor, Department of Endocrinology, Bangabandhu Sheik Mujib Medical University, Dhaka, Bangladeshen_US
dc.identifier.affiliationsAssistant Professor, Dept. of Endocrinology, Dhaka Medical College Hospital (DMCH), Dhaka, Bangladeshen_US
dc.identifier.affiliationsLecturer, Dept. of Community Medicine, Shahid Sayed Nazrul Islam Medical College, Kishoregonj, Bangladesen_US
dc.identifier.citationMostafa Hasan Rajib, Fariduddin Md., Selim Shahjada, Hasanat M A, Islam Moinul, Hoque Fazlul, Mustari Marufa, Mahjabeen Samira. Serum Zinc Level in Persons with Prediabetes and it’s Relation with Glycemic Status Attending Tertiary Care Hospital in Bangladesh. International Journal of Medical Research Professionals. 2020 Mar; 6(2): 63-68en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203581
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org//10..21276/ijmrp.2020.6.2.014en_US
dc.subjectDiabetes Mellitusen_US
dc.subjectSerum Zinc Levelen_US
dc.subjectPrediabetesen_US
dc.subjectGlycemic Statusen_US
dc.titleSerum Zinc Level in Persons with Prediabetes and it’s Relation with Glycemic Status Attending Tertiary Care Hospital in Bangladeshen_US
dc.typeJournal Articleen_US
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