Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity.

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dc.contributor.authorSwarnakar, Snehasiktaen_US
dc.contributor.authorPaul, Sumiten_US
dc.date.accessioned2009-02-21en_US
dc.date.accessioned2009-05-27T09:54:00Z
dc.date.available2009-02-21en_US
dc.date.available2009-05-27T09:54:00Z
dc.date.issued2009-02-21en_US
dc.description.abstractCurcumin, a polyphenol derived from turmeric (Curcuma longa) possesses diverse pharmacological properties including antioxidant, anti-inflammatory and antiproliferative activities. Endometriosis is a gyneocological disorder characterized by growth of endometrial tissues outside uterus that involves aberrant matrix remodeling. In this study the effect of curcumin was studied on surgically developed endometriosis in mice. Endometriosis with varying severity was developed in mice by peritoneal implantation of uterine fragments. The changes in matrix metalloproteinase (MMP)-9 and tissue inhibitor of metalloprotease (TIMP)-1 were investigated in endometriotic tissues following curcumin pre- and posttreatment. Results showed that MMP-9 activity increased gradually in endometriotic tissues with severity and curcumin treatment reversed the MMP-9 activity near to control value. Curcumin administered either post- or pre-endometriosis arrested endometriosis in a dose-dependent manner. It inhibited both MMP-9 activity and its expression at the level of secretion, during regression of endometriotic lesion. In addition, the attenuated activity of MMP-9 was associated with decreased expression of tumor necrosis factor-alpha (TNF-alpha) during healing, suggesting the anti-inflammatory property of curcumin. Moreover, curcumin pretreatment prevented lipid peroxidation and protein oxidation in endometriotic tissues. We reported here for the first time the anti-endometriotic property of curcumin via MMP-9 dependent pathway that may lead to new therapeutic intervention.en_US
dc.description.affiliationDepartment of Physiology, Drug Development Diagnostics and Biotechnology Division, Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India. snehasiktas@hotmail.comen_US
dc.identifier.citationSwarnakar S, Paul S. Curcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity. Indian Journal of Biochemistry & Biophysics. 2009 Feb; 46(1): 59-65en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/28893
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.meshAnalysis of Variance
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --therapeutic use
dc.subject.meshBlotting, Western
dc.subject.meshCurcumin --therapeutic use
dc.subject.meshDisease Models, Animal
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshEndometriosis --drug therapy
dc.subject.meshFemale
dc.subject.meshLipid Peroxidation --drug effects
dc.subject.meshMatrix Metalloproteinase 9 --metabolism
dc.subject.meshMice
dc.subject.meshMice, Inbred BALB C
dc.subject.meshOxidation-Reduction --drug effects
dc.subject.meshTime Factors
dc.subject.meshTissue Inhibitor of Metalloproteinase-1 --metabolism
dc.subject.meshTumor Necrosis Factor-alpha --metabolism
dc.subject.otherAnimals
dc.titleCurcumin arrests endometriosis by downregulation of matrix metalloproteinase-9 activity.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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