Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysis

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dc.contributor.authorWaghmare, Mandavien_US
dc.contributor.authorPagare, Sandeepen_US
dc.contributor.authorBhor, Ketakien_US
dc.contributor.authorSrivastava, Richaen_US
dc.contributor.authorManoj, Reemaen_US
dc.contributor.authorGavand, Kapilen_US
dc.date.accessioned2024-11-30T08:13:53Z
dc.date.available2024-11-30T08:13:53Z
dc.date.issued2024-07
dc.description.abstractBackground: Oral Submucous Fibrosis, OSF is an inflammatory mucosal disorder prevalent in areca nut chewing belts of the world. Although various treatments are available for its management, none provide complete res- olution.Curcumin, an indigenous product, improves burning sensation, mouth opening along with other clinical signs of OSF and is potentially viable therapeutic option for its management. Objectives: To assess the available evidence for employing curcumin in improving symptoms in patients with OSF. Methods: Systematic search was carried out in e-databases from January 2010 until July 2023 to identify relevant clinical trials comparing curcumin to active and/or nonactive controls (placebo) for the management of OSF. Results: A total of 20 studies were used for qualitative analysis out of which 11 studies were considered for quantitative synthesis.Curcumin was found to be highly effective in alleviating pain/burning sensation, improving mouth opening (MO), cheek flexibility, tongue protrusion and induces positive histological changes in patients with OSF.The standardized mean difference in mouth opening between both the Curcumin and Multi- vitamin group showed a statistically significant difference favouring the Curcumin group (SMD, 0.37, 95% CI = 0.18–0.56, p - 0.0001, I2- 0%). Conclusion: Statistically curcumin was noted to be as effective as Aloe vera, lycopene and steroids in relieving symptoms of OSF in stages 1 and 2 and improving MO. It is seen to improve histopathological picture of lesions thereby suggesting its active role in preventing malignant transformation. Its found to be more effective than multivitamins in improving mouth opening of patients in OSF.en_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Sector 7, Nerul, Navi, Mumbai, 400706, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, Indiaen_US
dc.identifier.affiliationsQuality, compliance and marketing, Masina Hospital, Byculla, Mumbai, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Medicine and Radiology, DY Patil Deemed to be University, School of Dentistry, Navi, Mumbai, 400706, Indiaen_US
dc.identifier.citationWaghmare Mandavi, Pagare Sandeep, Bhor Ketaki, Srivastava Richa, Manoj Reema, Gavand Kapil . Comparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysis. Journal of Ayurveda and Integrative Medicine. 2024 Jul; 15(4): 1-10en_US
dc.identifier.issn0975-9476
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/236974
dc.languageenen_US
dc.publisherElsevier B.V.en_US
dc.relation.issuenumber4en_US
dc.relation.volume15en_US
dc.source.urihttps://doi.org/10.1016/j.jaim.2024.100950en_US
dc.subjectCurcuminen_US
dc.subjectTrismusen_US
dc.subjectFibrosesen_US
dc.subjectOral submucousen_US
dc.titleComparing efficacy of curcumin with other treatment modalities in oral submucous fibrosis management - A systematic review and meta-analysisen_US
dc.typeJournal Articleen_US
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