Evaluation of neo adjuvant chemotherapy response in patients with locally advanced breast cancer

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dc.contributor.authorNallamothu, Murali Krishnaen_US
dc.contributor.authorC., Mandava Radha Manien_US
dc.contributor.authorVeera, Abhinav Chintaen_US
dc.contributor.authorT., Jaya Chandraen_US
dc.date.accessioned2020-05-06T08:34:24Z
dc.date.available2020-05-06T08:34:24Z
dc.date.issued2020-01
dc.description.abstractBackground:Carcinoma of the breast from the very beginning has been a feared disease. Advanced disease is treated by neoadjuvant chemotherapy (NACT). With this, a study was conducted to evaluate the pathologic response to NACT in locally advanced breast cancer.Methods:Study was conducted in GSL Medical College, approved by institutional ethics committee, females aged >18 years with locally advanced breast cancer were included in the study. Female <18 years and breast cancer male were not considered. The dimensions are marked and size of the lump compared before and after NACT. Chi-square test was used to find out the significance of study parameters; p<0.05 was considered statistically significant.Results:Total 110 patients were included in the study, mean age was50.63±10.76 years and 53% were in pre menopausal women. When pathological response was considered, 12.7% had complete response, 66.4% had partial response and 20.9% had no response to NACT; statistically there was significant difference between pre and post treatment tumor sizes (p<0.05).Conclusions: Most of the individuals belonged to premenopausal group. Tumour size showed significant decrease after NACT. The overall response rate (completeand partial) after NACTwas significant in our study groupen_US
dc.identifier.affiliationsDepartment of General Medicine, GSL Medical College, Rajahmundry, Andhra Pradesh , Indiaen_US
dc.identifier.affiliationsCentral Research Laboratory, GSL Medical College, Rajahmundry, Andhra Pradesh Indiaen_US
dc.identifier.citationNallamothu Murali Krishna, C. Mandava Radha Mani, Veera Abhinav Chinta, T. Jaya Chandra . Evaluation of neo adjuvant chemotherapy response in patients with locally advanced breast cancer. International Journal of Clinical Trials. 2020 Jan; 7(1): 32-34en_US
dc.identifier.issn2349-3240
dc.identifier.issn2349-3259
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/200962
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber1en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3259.ijct20200204en_US
dc.subjectBreasten_US
dc.subjectCanceren_US
dc.subjectChemotherapyen_US
dc.titleEvaluation of neo adjuvant chemotherapy response in patients with locally advanced breast canceren_US
dc.typeJournal Articleen_US
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