Prehyperuricemia Deserves More Attention in this Era of Metabolic Explosion: A Review

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dc.contributor.authorSubbu, GRen_US
dc.contributor.authorTiwaskar, Men_US
dc.contributor.authorMuruganathan, Aen_US
dc.contributor.authorRajasekar, R.en_US
dc.date.accessioned2025-08-13T09:16:16Z
dc.date.available2025-08-13T09:16:16Z
dc.date.issued2025-04
dc.description.abstractThe global population is experiencing a metabolic explosion, with the prevalence of hyperuricemia (HU) as a metabolic disorder and a causal factor for noncommunicable diseases (NCD) increasing rapidly worldwide over the last 2 decades. This rise is attributed to diets high in purine, alcohol, red meat, high-fructose foods, and lifestyle changes. The connection between HU and various NCDs is now stronger than ever. As HU progresses, systemic inflammation arises, leading to endothelial dysfunction and end-organ damage—molecular changes that were previously unrecognized. HU is increasingly seen as a metabolic disorder, particularly a vascular disorder rather than just a crystallization disease. Asymptomatic HU is no longer considered benign, and it should not be equated with gout. It is crucial to diagnose HU early, at a high normal level, and manage it to prevent the development and complications of related extra-articular diseases. For broader recognition and significance, this high normal level of serum uric acid (UA) should be termed prehyperuricemia (PHU). Like prediabetes and prehypertension, PHU should be identified early, regardless of age and sex, with preventive actions implemented to maintain UA at a safer level.en_US
dc.identifier.affiliationsPhysician, Department of Medicine, St Joseph’s Hospital, Ernakulam, Kerala, Indiaen_US
dc.identifier.affiliationsPhysician, Department of Medicine, Shilpa Medical Centre, Mumbai, Maharashtra, Indiaen_US
dc.identifier.affiliationsAG Hospital, Tirupur, Kumbakonam, Tamil Nadu, Indiaen_US
dc.identifier.affiliationsHeart and Diabetes Centre, Kumbakonam, Tamil Nadu, Indiaen_US
dc.identifier.citationSubbu GR, Tiwaskar M, Muruganathan A, Rajasekar R.. Prehyperuricemia Deserves More Attention in this Era of Metabolic Explosion: A Review. Journal of the Association of Physicians of India. 2025 Apr; 73(4): 69-74en_US
dc.identifier.issn0004-5772
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/251965
dc.languageenen_US
dc.publisherJournal of Indian Medical Associationen_US
dc.relation.issuenumber4en_US
dc.relation.volume73en_US
dc.source.urihttps://doi.org/10.59556/japi.73.0905en_US
dc.titlePrehyperuricemia Deserves More Attention in this Era of Metabolic Explosion: A Reviewen_US
dc.typeJournal Articleen_US
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