Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22).

Simple item page
dc.contributor.authorGadage, V S
dc.contributor.authorAmare, P S Kadam
dc.contributor.authorGalani, K S
dc.contributor.authorMittal, N
dc.date.accessioned2012-10-18T08:42:08Z
dc.date.available2012-10-18T08:42:08Z
dc.date.issued2012-07
dc.description.abstractSystemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD) is a subtype of mastocytosis associated commonly with myeloid neoplasms, Non-Hodgkin's lymphoma, or other hematological neoplasms. In these conditions, mastocytosis needs to be differentiated from mast cell hyperplasia or mast cell activation states. Neoplastic nature of mastocytosis is proved either by morphology, aberrant immunophenotype, or detection of point mutation at codon-816 of c-kit gene. This is a rare entity, even more so in pediatric population. Herein, we report a case of 14-year-old girl with SM associated with acute myeloid leukemia with maturation with t(8;21). Multifocal dense infiltrate of spindle-shaped mast cells on bone marrow aspirate and biopsy with coexpression of CD2 and CD25 by flow cytometric analysis proved the SM component at the time of diagnosis and persistence at post induction status also.en_US
dc.identifier.citationGadage V S, Amare P S Kadam, Galani K S, Mittal N. Systemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22). Indian Journal of Pathology & Microbiology. 2012 Jul-Sept 55(3): 409-412.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/142284
dc.language.isoenen_US
dc.source.urihttps://www.ijpmonline.org/article.asp?issn=0377-4929;year=2012;volume=55;issue=3;spage=409;epage=412;aulast=Gadageen_US
dc.subjectAcute leukemiaen_US
dc.subjectacute myeloid leukemiaen_US
dc.subjectmastocytosisen_US
dc.subject.meshAdolescent
dc.subject.meshAntigens, CD2 --analysis
dc.subject.meshBone Marrow --pathology
dc.subject.meshFemale
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshInterleukin-2 Receptor alpha Subunit --analysis
dc.subject.meshLeukemia, Myeloid, Acute --complications
dc.subject.meshLeukemia, Myeloid, Acute --diagnosis
dc.subject.meshMastocytosis, Systemic --complications
dc.subject.meshMastocytosis, Systemic --diagnosis
dc.subject.meshMicroscopy
dc.subject.meshTranslocation, Genetic
dc.titleSystemic mastocytosis with associated acute myeloid leukemia with t (8; 21) (q22; q22).en_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijpm2012v55n3p409.pdf
Size:
3.33 MB
Format:
Adobe Portable Document Format
Description:
Journal article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Indian Journal of Pathology & Microbiology