Detection without deflection? A hypothesis for direct sensing of sound pressure by hair cells.

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dc.contributor.authorBell, Andrewen_US
dc.date.accessioned2007-03-17en_US
dc.date.accessioned2009-06-01T14:57:13Z
dc.date.available2007-03-17en_US
dc.date.available2009-06-01T14:57:13Z
dc.date.issued2007-03-17en_US
dc.description118 references.en_US
dc.description.abstractIt is widely thought that organisms detect sound by sensing the deflection of hair-like projections, the stereocilia, at the apex of hair cells. In the case of mammals, the standard interpretation is that hair cells in the cochlea respond to deflection of stereocilia induced by motion generated by a hydrodynamic travelling wave. But in the light of persistent anomalies, an alternative hypothesis seems to have some merit: that sensing cells (in particular the outer hair cells) may, at least at low intensities, be reacting to a different stimulus - the rapid pressure wave that sweeps through the cochlear fluids at the speed of sound in water. This would explain why fast responses are sometimes seen before the peak of the travelling wave. Yet how could cells directly sense fluid pressure? Here, a model is constructed of the outer hair cell as a pressure vessel able to sense pressure variations across its cuticular pore, and this 'fontanelle' model, based on the sensing action of the basal body at this compliant spot, could explain the observed anomalies. Moreover, the fontanelle model can be applied to a wide range of other organisms, suggesting that direct pressure detection is a general mode of sensing complementary to stereociliar displacement.en_US
dc.description.affiliationResearch School of Biological Sciences, The Australian National University, Canberra, ACT 0200, Australia. andrew.bell@anu.edu.auen_US
dc.identifier.citationBell A. Detection without deflection? A hypothesis for direct sensing of sound pressure by hair cells. Journal of Biosciences. 2007 Mar; 32(2): 385-404en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/111196
dc.language.isoengen_US
dc.source.urihttps://www.ias.ac.in/jbiosci/index.htmlen_US
dc.subject.meshAiren_US
dc.subject.meshAnimalsen_US
dc.subject.meshHair Cells, Auditory --physiologyen_US
dc.subject.meshHearing --physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshModels, Biologicalen_US
dc.subject.meshSounden_US
dc.titleDetection without deflection? A hypothesis for direct sensing of sound pressure by hair cells.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeReviewen_US
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