High Dose Statins: Is it Beneficial over Conventional Dose of Statin in Acute Coronary Syndrome.
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Date
2010
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Abstract
Increasing burden of cardiovascular disease risk factors has led to increase in the incidence in the
coronary artery disease (CAD). Advancements in medical and surgical care of patients with heart
disease have led to a large number of people surviving acute coronary events. Patients with acute
coronary syndrome (ACS) are at high risk for recurrent coronary events, sudden death, and all cause
mortality. Conventional revascularization therapies reduce the risk of further ischaemia but do not
affect the underlying atherosclerotic disease. Statins have a proven record in the secondary prevention
of coronary heart disease. Furthermore, statins have been shown to exert various pleotropic effects,
which may stabilize vulnerable atherosclerotic plaques. Therefore, initiating, statin therapy in
patients with established CAD is both beneficial and more cost effective. Trials conducted in recent
times have addressed the issue of whether higher dose statin therapy provides further reductions in
the risks of cardiovascular events following an acute coronary syndrome diagnosis, over and above
that provided by a conventional dose statin regimen. However, recent trials of high dose statin
therapy in patients with acute coronary syndromes have yielded conflicting results. The aim of this
article is to provide a critical and up-to-date summary of the findings of clinical trials of intensive
statin therapy, including a brief overview of safety and efficacy of such treatments.
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Keywords
Statin, Acute coronary syndrome
Citation
Islam A E M M, Mazumder A A S. High Dose Statins: Is it Beneficial over Conventional Dose of Statin in Acute Coronary Syndrome. Cardiovascular Journal. 2010; 2(2): 245-251.