Prolactin and cortisol levels in seizure disorders.

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dc.contributor.authorMehta, S Ren_US
dc.contributor.authorDham, S Ken_US
dc.contributor.authorLazar, A Ien_US
dc.contributor.authorNarayanswamy, A Sen_US
dc.contributor.authorPrasad, G Sen_US
dc.date.accessioned1994-09-01en_US
dc.date.accessioned2009-05-31T03:43:27Z
dc.date.available1994-09-01en_US
dc.date.available2009-05-31T03:43:27Z
dc.date.issued1994-09-01en_US
dc.description.abstractLevels of prolactin (PRL) and cortisol were estimated to find out the acute effects of generalised tonic clonic seizures (GTCS), partial seizures and pseudoseizures in 60, 18 and 9 patients respectively. Prolactin levels were estimated at 20, 60 and 120 minutes whereas, cortisol was estimated at 20, 60, and 120 minutes postictally. Cortisol and PRL estimation was also done in 10 healthy controls and 11 patients of epilepsy during interictal phase. Serum PRL levels were elevated (> 25 ng/ml) in 68.33% of GTCS and 11.11% of partial seizure cases. The peak levels were achieved in first 30 minutes after the seizures with a gradual return to base line during subsequent one hour. None of the patients with pseudoseizure showed any rise in serum PRL levels. The interictal PRL levels were normal in all the epileptics. Plasma cortisol levels were elevated during 60 to 120 minute postictal period in 45% of GTCS, 55.55% of partial seizures and 66.66% of pseudoseizure patients. Cortisol appears to be non-selectively triggered by all stressful events but postictal PRL estimation can help in differentiating pseudoseizures from GTCS. While an elevated PRL indicates the occurrence of grandmal seizure, a normal postictal PRL level does not always exclude epileptic seizure, specially a partial seizure.en_US
dc.description.affiliationArmed Forces Medical College, Pune.en_US
dc.identifier.citationMehta SR, Dham SK, Lazar AI, Narayanswamy AS, Prasad GS. Prolactin and cortisol levels in seizure disorders. Journal of the Association of Physicians of India. 1994 Sep; 42(9): 709-12en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/94146
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisone --blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProlactin --blooden_US
dc.subject.meshSeizures --blooden_US
dc.titleProlactin and cortisol levels in seizure disorders.en_US
dc.typeJournal Articleen_US
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