Movability of advanced third-stage larva of Gnathostoma spinigerum exposed to albendazole sulphoxide in vitro.

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dc.contributor.authorSukontason, Ken_US
dc.contributor.authorKlaolaor, Pen_US
dc.contributor.authorSukontason, Ken_US
dc.contributor.authorMorakote, Nen_US
dc.contributor.authorMuangyimpong, Yen_US
dc.contributor.authorChaithong, Uen_US
dc.date.accessioned2009-05-27T15:09:22Z
dc.date.available2009-05-27T15:09:22Z
dc.date.issued1999-06-25en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractMovability of advanced third-stage larvae of Gnathostoma spinigerum exposed to albendazole sulphoxide (AlbSO), the active metabolite of albendazole, was determined in vitro. Larvae in control groups moved actively with the whole body for all 21 days of the study period. In larvae treated with AlbSO 1 microg/ml, the movement was significantly reduced after 11 days exposed to the drug and to be only a part of body on the 15th-21st days. In larvae treated with AlbSO 2 microg/ml, the movement was initiated in decreasing after 9th days and to be only a part of body on the 12th-17th days. Finally, worms were immobile but not dead on the 20th-21st days. Although there was no larvae died at 21st days exposed to AlbSO in both concentrations; but all worms were sluggish and may die later. These lethargic worms may not be able to migrate in patients and leading to cure. Albendazole may not be benefit for acute symptom clearance; however, it can prevent the recurrent migratory swelling after the treatment of 21 day-course.en_US
dc.description.affiliationDepartment of Parasitology, Faculty of Medicine, Chiang Mai University, Thailand. ksukonta@sd01.med.cmu.ac.then_US
dc.identifier.citationSukontason K, Klaolaor P, Sukontason K, Morakote N, Muangyimpong Y, Chaithong U. Movability of advanced third-stage larva of Gnathostoma spinigerum exposed to albendazole sulphoxide in vitro. The Southeast Asian Journal of Tropical Medicine and Public Health. 1999 Jun; 30(2): 379-81en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/32058
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/1999-30-2/1999-30-2-379.pdfen_US
dc.subject.meshAlbendazole --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnthelmintics --pharmacologyen_US
dc.subject.meshGnathostoma --drug effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshLarva --drug effectsen_US
dc.subject.meshMovement --drug effectsen_US
dc.subject.meshSpirurida Infections --drug therapyen_US
dc.titleMovability of advanced third-stage larva of Gnathostoma spinigerum exposed to albendazole sulphoxide in vitro.en_US
dc.typeIn Vitroen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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