New bisnorsesquiterpene from Glottiphyllum linguiforme and its antimicrobial, cytotoxic, and antioxidant activities

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dc.contributor.authorAhmed, HSen_US
dc.contributor.authorAmir, DEen_US
dc.contributor.authorMuhaisen, HMHen_US
dc.contributor.authorSebak, Men_US
dc.contributor.authorAbdelghany, TMen_US
dc.contributor.authorElmaidomy, AHen_US
dc.contributor.authorAmin, Een_US
dc.contributor.authorOwis, AIen_US
dc.contributor.authorOrabi, MAAen_US
dc.contributor.authorAfifi, N.en_US
dc.date.accessioned2024-11-30T11:21:19Z
dc.date.available2024-11-30T11:21:19Z
dc.date.issued2024-06
dc.description.abstractNatural product research is a cornerstone in the drug discovery process. Many inspiring chemical moieties with new skeletons and potent biological activity are commonly reported from natural sources. Chromatographic examination of the alcoholic extract of Glottiphyllum linguiforme aerial furnished four compounds, including ?-sitosterol (1), ?-sitosterol-3-O-?-D-glucopyranoside (2), and 1,1? biuracil (3), and a new compound, tectoionyl A 3-O-sodium sulfate (4). The new structure was elucidated using high-resolution mass and intensive 1D and 2D NMR spectroscopic analyses. Quantitative analysis of G. linguiforme extract revealed considerable contents of total phenolic and total flavonoid. A DPPH antioxidant assay indicated moderate activity (0.026 mg acid equivalent antioxidant capacity/g dry extract). Antimicrobial activity testing of the pure compounds indicated noticeable antibacterial activity of compound 2 against Escherichia coli, Salmonella enterica, and Pseudomonas aeruginosa. In addition, compounds 1–4 displayed mild cytotoxic effects against human breast adenocarcinoma (MCF7) and hepatocellular carcinoma (HepG2) cell lines, and the normal (Vero) cells at the tested concentration (100 ?g/ml), as compared to the standard cytotoxic drug, doxorubicin. This study is the first to estimate phenolics and flavonoid contents, discover constituents by phytochemical isolation, and examine cytotoxicity and antimicrobial properties of G. linguiforme. The unusual nitrogenous compound 1,1?-biuracil (3) and the sulfate derivative (4) may evidence chemotaxonomic importance.en_US
dc.identifier.affiliationsPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypten_US
dc.identifier.affiliationsPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypten_US
dc.identifier.affiliationsDepartment of Chemistry, Faculty of Science and Arts, Najran University, Sharurah, Saudi Arabiaen_US
dc.identifier.affiliationsMicrobiology and Immunology Department, Faculty of Pharmacy, Beni-Suef University, Egypten_US
dc.identifier.affiliationsPharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo Egypt; Pharmacology and Toxicology Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypten_US
dc.identifier.affiliationsPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypten_US
dc.identifier.affiliationsDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Qassim University, Buraydah, Saudi Arabiaen_US
dc.identifier.affiliationsPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt; Pharmacognosy Department, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypten_US
dc.identifier.affiliationsDepartment of Pharmacognosy, College of Pharmacy, Najran University, Najran, Saudi Arabiaen_US
dc.identifier.affiliationsPharmacognosy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypten_US
dc.identifier.citationAhmed HS, Amir DE, Muhaisen HMH, Sebak M, Abdelghany TM, Elmaidomy AH, Amin E, Owis AI, Orabi MAA, Afifi N. . New bisnorsesquiterpene from Glottiphyllum linguiforme and its antimicrobial, cytotoxic, and antioxidant activities. Journal of Applied Pharmaceutical Science. 2024 Jun; 14(6): 97-104en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/237690
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber6en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.7324/JAPS.2024.173477en_US
dc.subjectGlottiphyllum linguiformeen_US
dc.subjecttectoionyl A-3-O-sodium sulfateen_US
dc.subjectantioxidanten_US
dc.subjectantimicrobialen_US
dc.subjectcytotoxicity.en_US
dc.titleNew bisnorsesquiterpene from Glottiphyllum linguiforme and its antimicrobial, cytotoxic, and antioxidant activitiesen_US
dc.typeJournal Articleen_US
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