Therapeutic success of tofacitinib in granuloma annulare: A retrospective case series of 15 patients

Simple item page
dc.contributor.authorDev, Aen_US
dc.contributor.authorKeshavamurthy, Ven_US
dc.contributor.authorChatterjee, D.en_US
dc.date.accessioned2025-06-18T11:42:23Z
dc.date.available2025-06-18T11:42:23Z
dc.date.issued2025-02
dc.description.abstractBackground: Granuloma annulare (GA) is a necrobiotic granulomatous disorder that may sometimes be resistant to treatment, especially the generalised form. Tofacitinib has recently shown promise in the treatment of non-infective granulomatous dermatosis. Objectives: In this study, we aimed to evaluate the response of generalised GA to oral tofacitinib. Methods: This was a retrospective case series in patients of generalised GA who were treated with oral tofacitinib 5 mg twice a day in a tertiary care centre in north India. Baseline clinical details and histopathological findings were reviewed. Treatment response was noted in the form of clearance of lesions (complete or partial) along with the time taken to achieve the maximum response. Results: A total of 15 patients of generalised GA were included in this study, amongst whom nine patients were resistant to conventional therapies whilst the remaining were treatment naïve. Complete clearance of lesions was noted in 11 patients at a mean treatment duration of 4.4 ± 2.1 months whereas clearance was partial in four, with a mean follow-up duration post- treatment in patients who had partial clearance, which is 7.3 ± 2.8 month, with a reduction in erythema and infiltration in those lesions. Adverse effects in the form of hyperlipidemia were observed in two patients. Conclusion: Tofacitinib, a JAK-STAT inhibitor is beneficial in treating GA, especially in those with generalised and recalcitrant disease.en_US
dc.identifier.affiliationsDepartment of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Dermatology, Venereology and Leprology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, PGIMER, Chandigarh, Indiaen_US
dc.identifier.citationDev A, Keshavamurthy V, Chatterjee D.. Therapeutic success of tofacitinib in granuloma annulare: A retrospective case series of 15 patients. Indian Journal of Dermatology, Venereology and Leprology. 2025 Feb; 91(1): 65-70en_US
dc.identifier.issn0378-6323
dc.identifier.issn0973-3922
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/249404
dc.languageenen_US
dc.publisherScientific Scholar on behalf of Indian Association of Dermatologists, Venereologists & Leprologists (IADVL), India.en_US
dc.relation.issuenumber1en_US
dc.relation.volume91en_US
dc.source.urihttps://dx.doi.org/10.25259/IJDVL_215_2024en_US
dc.subjectgranuloma annulareen_US
dc.subjecttofacitiniben_US
dc.subjectJAK-STATen_US
dc.titleTherapeutic success of tofacitinib in granuloma annulare: A retrospective case series of 15 patientsen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ijdvl2025v91n1p65.pdf
Size:
2.62 MB
Format:
Adobe Portable Document Format
Download
Collections
Indian Journal of Dermatology, Venereology and Leprology