A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic.

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dc.contributor.authorGhose, Supriyoen_US
dc.contributor.authorBiswas, Nihar Ren_US
dc.contributor.authorDas, Gopal Ken_US
dc.contributor.authorSethi, Anitaen_US
dc.contributor.authorVerma, Basanten_US
dc.contributor.authorJhingan, Shuchitaen_US
dc.contributor.authorPandey, Ravindra Men_US
dc.date.accessioned2004-10-24en_US
dc.date.accessioned2009-06-01T08:16:38Z
dc.date.available2004-10-24en_US
dc.date.available2009-06-01T08:16:38Z
dc.date.issued2004-10-24en_US
dc.description.abstractIn this study, the ocular surface anaesthetic and analgesic efficacies of 0.5% and 1% centbucridine both in saline were compared with 4% lignocaine drops in distilled water in normal healthy volunteers divided into three equal groups. In 99 healthy eyes, keeping one eye as an unanaesthetized control, one drop of any of the above three coded drugs was instilled in the contralateral eye, followed by one more drop of the same drug in the same eye after 3 minutes. The oneset of anaesthesia, achievement and duration of peak activity, total duration of action, the depth of analgesia, and period of burning sensation were all noted in this double-masked randomized controlled trial with the various drug solutions. Total peak duration of anaesthetic as well as analgesic effects in the 99 healthy normal eyes were found to be the highest with centbucridine 1%, followed by 4% lignocaine and 0.5% centbucridine respectively.en_US
dc.description.affiliationRajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029en_US
dc.identifier.citationGhose S, Biswas NR, Das GK, Sethi A, Verma B, Jhingan S, Pandey RM. A prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic. Indian Journal of Physiology and Pharmacology. 2004 Oct; 48(4): 466-70en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108790
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnesthetics, Local --pharmacologyen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshHumansen_US
dc.subject.meshLidocaine --pharmacologyen_US
dc.subject.meshOphthalmologic Surgical Proceduresen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshTacrine --analogs & derivativesen_US
dc.titleA prospective randomized double masked controlled clinical trial to determine the efficacy of multiple drop centbucridine as an ocular surface anaesthetic.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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