Exchange transfusion therapy in severe complicated malaria.

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dc.contributor.authorSrichaikul, Ten_US
dc.contributor.authorLeelasiri, Aen_US
dc.contributor.authorPolvicha, Pen_US
dc.contributor.authorMongkonsritragoon, Wen_US
dc.contributor.authorPrayoonwiwat, Wen_US
dc.contributor.authorLeelarsupasri, Sen_US
dc.contributor.authorPuetpol, Sen_US
dc.date.accessioned2009-05-27T16:43:53Z
dc.date.available2009-05-27T16:43:53Z
dc.date.issued1993-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractNine cases of severe complicated falciparum malaria treated by exchange transfusion were studied. Eight patients survived and one patient died. Multisystemic complications were found in all cases. The CNS complications, acute renal failure, pulmonary insufficiency, jaundice, bleeding, sepsis, and DIC were found in 9, 7, 5, 7, 2, 4 and 1 cases, respectively. The fatal case presented with severe multisystemic complications together with 40% parasitemia. In eight survivors, whose parasitemia ranged from 0.3%, to 90%, had milder degrees of systemic complications. With the use of blood exchange 10-15 units, the parasitemia was decreased to less than 5% within 24 hours in all expect one who had parasitemia 90%. In comparison with the other 10 matched non-exchanged patients, there was no significant difference in survival rate between these two group (89% vs 80%). However, in the patients with ARDS the survival rate in the group who received the exchange transfusion therapy was superior (75% vs 0%). The exchange transfusion therapy is therefore strongly recommended in the treatment of malarial patients who present with parasitemia > 30% and severe systemic complications, particularly those who have severe acute renal failure or have lung complications. The amount of blood used for exchange transfusion should at least 1.2 times the blood volume for rapid removal of parasites and toxic metabolites from the circulation.en_US
dc.description.affiliationHematology Division, Pramongkutklao Hospital, College of Medicine, Bangkok, Thailand.en_US
dc.identifier.citationSrichaikul T, Leelasiri A, Polvicha P, Mongkonsritragoon W, Prayoonwiwat W, Leelarsupasri S, Puetpol S. Exchange transfusion therapy in severe complicated malaria. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 ; 24 Suppl 1(): 100-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/35882
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshExchange Transfusion, Whole Blood --methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMalaria, Falciparum --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshParasitemia --therapyen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshSurvival Analysisen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleExchange transfusion therapy in severe complicated malaria.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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